Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy

Deep brain stimulation (DBS) is a promising treatment for drug‐refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory...

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Autores principales: Vakilna, Yash Shashank, Chaitanya, Ganne, Hafeez, Muhammad Ubaid, Ilyas, Adeel, Saranathan, Manojkumar, Gavvala, Jay, Tandon, Nitin, Pati, Sandipan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351657/
https://www.ncbi.nlm.nih.gov/pubmed/37231611
http://dx.doi.org/10.1002/acn3.51815
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author Vakilna, Yash Shashank
Chaitanya, Ganne
Hafeez, Muhammad Ubaid
Ilyas, Adeel
Saranathan, Manojkumar
Gavvala, Jay
Tandon, Nitin
Pati, Sandipan
author_facet Vakilna, Yash Shashank
Chaitanya, Ganne
Hafeez, Muhammad Ubaid
Ilyas, Adeel
Saranathan, Manojkumar
Gavvala, Jay
Tandon, Nitin
Pati, Sandipan
author_sort Vakilna, Yash Shashank
collection PubMed
description Deep brain stimulation (DBS) is a promising treatment for drug‐refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory seizure monitoring using spectral fingerprinting (12.15–17.15 Hz) recorded through Medtronic Percept DBS implanted bilaterally in the medial pulvinar thalami. This technology offers unprecedented opportunities for real‐time monitoring of seizure burden and thalamocortical network modulation for effective seizure reduction in patients with bilateral mesial temporal and temporal plus epilepsies that are not suitable for resection.
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spelling pubmed-103516572023-07-18 Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy Vakilna, Yash Shashank Chaitanya, Ganne Hafeez, Muhammad Ubaid Ilyas, Adeel Saranathan, Manojkumar Gavvala, Jay Tandon, Nitin Pati, Sandipan Ann Clin Transl Neurol Case Study Deep brain stimulation (DBS) is a promising treatment for drug‐refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case study presents the application of ambulatory seizure monitoring using spectral fingerprinting (12.15–17.15 Hz) recorded through Medtronic Percept DBS implanted bilaterally in the medial pulvinar thalami. This technology offers unprecedented opportunities for real‐time monitoring of seizure burden and thalamocortical network modulation for effective seizure reduction in patients with bilateral mesial temporal and temporal plus epilepsies that are not suitable for resection. John Wiley and Sons Inc. 2023-05-25 /pmc/articles/PMC10351657/ /pubmed/37231611 http://dx.doi.org/10.1002/acn3.51815 Text en © 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Study
Vakilna, Yash Shashank
Chaitanya, Ganne
Hafeez, Muhammad Ubaid
Ilyas, Adeel
Saranathan, Manojkumar
Gavvala, Jay
Tandon, Nitin
Pati, Sandipan
Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy
title Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy
title_full Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy
title_fullStr Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy
title_full_unstemmed Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy
title_short Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy
title_sort pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351657/
https://www.ncbi.nlm.nih.gov/pubmed/37231611
http://dx.doi.org/10.1002/acn3.51815
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