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Gamified assessment of cognitive performance during moderate hypoxia

INTRODUCTION: There is a need for rapid and objective assessment tools to identify people at risk of impaired cognitive function during hypoxia. PURPOSE: To test the hypotheses that performance on gamified cognitive tests examining the cognitive domains of executive function (Gridshot), working memo...

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Autores principales: Keeler, Jason M., Tourula, Erica, Hite, M. Jo, Listman, Jennifer B., Heeger, David J., Port, Nicholas L., Schlader, Zachary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351691/
https://www.ncbi.nlm.nih.gov/pubmed/37459310
http://dx.doi.org/10.1371/journal.pone.0288201
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author Keeler, Jason M.
Tourula, Erica
Hite, M. Jo
Listman, Jennifer B.
Heeger, David J.
Port, Nicholas L.
Schlader, Zachary J.
author_facet Keeler, Jason M.
Tourula, Erica
Hite, M. Jo
Listman, Jennifer B.
Heeger, David J.
Port, Nicholas L.
Schlader, Zachary J.
author_sort Keeler, Jason M.
collection PubMed
description INTRODUCTION: There is a need for rapid and objective assessment tools to identify people at risk of impaired cognitive function during hypoxia. PURPOSE: To test the hypotheses that performance on gamified cognitive tests examining the cognitive domains of executive function (Gridshot), working memory (Capacity) and spatial tracking (Multitracker) will be reduced during normobaric exposure to moderate normobaric hypoxia. METHODS: Following three consecutive days of practice, twenty-one healthy adults (27 ± 5 y, 9 females) completed five 1-min rounds of the tablet-based games Gridshot, Capacity, and Multitracker (Statespace Labs, Inc.) at Baseline and 60 and 90 min after exposure to 14.0 ± 0.2% (hypoxia) and 20.6 ± 0.3% (normoxia) oxygen. Both conditions were completed on the same day and were administered in a single-blind, block randomized manner. Arterial oxyhemoglobin saturation was estimated via forehead pulse oximetry (SpO(2)). Data were analyzed using ANCOVA with a covariate of Baseline. RESULTS: Compared to normoxia (98 ± 1%), SpO(2) was lower (p < 0.001) at 60 (91 ± 3%) and 90 (91 ± 2%) min of hypoxia. No condition x time interaction effects were identified for any gamified cognitive tests (p ≥ 0.32). A main effect of condition was identified for Capacity (p = 0.05) and Multitracker (p = 0.04), but not Gridshot (p = 0.33). Post hoc analyses of the composite scores for both Capacity (p = 0.11) and Multitracker (p = 0.73) demonstrated no difference between conditions. CONCLUSION: Performance on gamified cognitive tests was not consistently affected by acute normobaric moderate hypoxic exposure.
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spelling pubmed-103516912023-07-18 Gamified assessment of cognitive performance during moderate hypoxia Keeler, Jason M. Tourula, Erica Hite, M. Jo Listman, Jennifer B. Heeger, David J. Port, Nicholas L. Schlader, Zachary J. PLoS One Research Article INTRODUCTION: There is a need for rapid and objective assessment tools to identify people at risk of impaired cognitive function during hypoxia. PURPOSE: To test the hypotheses that performance on gamified cognitive tests examining the cognitive domains of executive function (Gridshot), working memory (Capacity) and spatial tracking (Multitracker) will be reduced during normobaric exposure to moderate normobaric hypoxia. METHODS: Following three consecutive days of practice, twenty-one healthy adults (27 ± 5 y, 9 females) completed five 1-min rounds of the tablet-based games Gridshot, Capacity, and Multitracker (Statespace Labs, Inc.) at Baseline and 60 and 90 min after exposure to 14.0 ± 0.2% (hypoxia) and 20.6 ± 0.3% (normoxia) oxygen. Both conditions were completed on the same day and were administered in a single-blind, block randomized manner. Arterial oxyhemoglobin saturation was estimated via forehead pulse oximetry (SpO(2)). Data were analyzed using ANCOVA with a covariate of Baseline. RESULTS: Compared to normoxia (98 ± 1%), SpO(2) was lower (p < 0.001) at 60 (91 ± 3%) and 90 (91 ± 2%) min of hypoxia. No condition x time interaction effects were identified for any gamified cognitive tests (p ≥ 0.32). A main effect of condition was identified for Capacity (p = 0.05) and Multitracker (p = 0.04), but not Gridshot (p = 0.33). Post hoc analyses of the composite scores for both Capacity (p = 0.11) and Multitracker (p = 0.73) demonstrated no difference between conditions. CONCLUSION: Performance on gamified cognitive tests was not consistently affected by acute normobaric moderate hypoxic exposure. Public Library of Science 2023-07-17 /pmc/articles/PMC10351691/ /pubmed/37459310 http://dx.doi.org/10.1371/journal.pone.0288201 Text en © 2023 Keeler et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Keeler, Jason M.
Tourula, Erica
Hite, M. Jo
Listman, Jennifer B.
Heeger, David J.
Port, Nicholas L.
Schlader, Zachary J.
Gamified assessment of cognitive performance during moderate hypoxia
title Gamified assessment of cognitive performance during moderate hypoxia
title_full Gamified assessment of cognitive performance during moderate hypoxia
title_fullStr Gamified assessment of cognitive performance during moderate hypoxia
title_full_unstemmed Gamified assessment of cognitive performance during moderate hypoxia
title_short Gamified assessment of cognitive performance during moderate hypoxia
title_sort gamified assessment of cognitive performance during moderate hypoxia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351691/
https://www.ncbi.nlm.nih.gov/pubmed/37459310
http://dx.doi.org/10.1371/journal.pone.0288201
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