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APOE-ε4 synergizes with sleep disruption to accelerate Aβ deposition and Aβ-associated tau seeding and spreading

Alzheimer’s disease (AD) is the most common cause of dementia. The APOE-ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset AD. The APOE genotype modulates the effect of sleep disruption on AD risk, suggesting a possible link between apoE and sleep in AD...

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Detalles Bibliográficos
Autores principales:	Wang, Chanung, Nambiar, Aishwarya, Strickland, Michael R., Lee, Choonghee, Parhizkar, Samira, Moore, Alec C., Musiek, Erik S., Ulrich, Jason D., Holtzman, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351966/ https://www.ncbi.nlm.nih.gov/pubmed/37279069 http://dx.doi.org/10.1172/JCI169131

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