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Inflammatory Bowel Disease and Neurodegenerative Diseases

A growing body of evidence has demonstrated an intricate association between inflammatory bowel disease (IBD) and neurodegenerative conditions, expanding beyond previous foci of comorbidities between IBD and mood disorders. These new discoveries stem from an improved understanding of the gut-microbi...

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Autores principales: Kim, Jin Sun, Chen, Mu-Hong, Wang, Hohui E., Lu, Ching-Liang, Wang, Yen-Po, Zhang, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352055/
https://www.ncbi.nlm.nih.gov/pubmed/36843420
http://dx.doi.org/10.5009/gnl220523
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author Kim, Jin Sun
Chen, Mu-Hong
Wang, Hohui E.
Lu, Ching-Liang
Wang, Yen-Po
Zhang, Bing
author_facet Kim, Jin Sun
Chen, Mu-Hong
Wang, Hohui E.
Lu, Ching-Liang
Wang, Yen-Po
Zhang, Bing
author_sort Kim, Jin Sun
collection PubMed
description A growing body of evidence has demonstrated an intricate association between inflammatory bowel disease (IBD) and neurodegenerative conditions, expanding beyond previous foci of comorbidities between IBD and mood disorders. These new discoveries stem from an improved understanding of the gut-microbiome-brain axis: specifically, the ability of the intestinal microbiota to modulate inflammation and regulate neuromodulatory compounds. Clinical retrospective studies incorporating large sample sizes and population-based cohorts have demonstrated and confirmed the relevance of IBD and chronic neurodegeneration in clinical medicine. In this review, we expound upon the current knowledge on the gut-microbiome-brain axis, highlighting several plausible mechanisms linking IBD with neurodegeneration. We also summarize the known associations between IBD with Parkinson disease, Alzheimer disease, vascular dementia and ischemic stroke, and multiple sclerosis in a clinical context. Finally, we discuss the implications of an improved understanding of the gut-microbiome-brain axis in preventing, diagnosing, and managing neurodegeneration among IBD and non-IBD patients.
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spelling pubmed-103520552023-07-18 Inflammatory Bowel Disease and Neurodegenerative Diseases Kim, Jin Sun Chen, Mu-Hong Wang, Hohui E. Lu, Ching-Liang Wang, Yen-Po Zhang, Bing Gut Liver Review A growing body of evidence has demonstrated an intricate association between inflammatory bowel disease (IBD) and neurodegenerative conditions, expanding beyond previous foci of comorbidities between IBD and mood disorders. These new discoveries stem from an improved understanding of the gut-microbiome-brain axis: specifically, the ability of the intestinal microbiota to modulate inflammation and regulate neuromodulatory compounds. Clinical retrospective studies incorporating large sample sizes and population-based cohorts have demonstrated and confirmed the relevance of IBD and chronic neurodegeneration in clinical medicine. In this review, we expound upon the current knowledge on the gut-microbiome-brain axis, highlighting several plausible mechanisms linking IBD with neurodegeneration. We also summarize the known associations between IBD with Parkinson disease, Alzheimer disease, vascular dementia and ischemic stroke, and multiple sclerosis in a clinical context. Finally, we discuss the implications of an improved understanding of the gut-microbiome-brain axis in preventing, diagnosing, and managing neurodegeneration among IBD and non-IBD patients. Editorial Office of Gut and Liver 2023-07-15 2023-02-27 /pmc/articles/PMC10352055/ /pubmed/36843420 http://dx.doi.org/10.5009/gnl220523 Text en Copyright © Gut and Liver. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kim, Jin Sun
Chen, Mu-Hong
Wang, Hohui E.
Lu, Ching-Liang
Wang, Yen-Po
Zhang, Bing
Inflammatory Bowel Disease and Neurodegenerative Diseases
title Inflammatory Bowel Disease and Neurodegenerative Diseases
title_full Inflammatory Bowel Disease and Neurodegenerative Diseases
title_fullStr Inflammatory Bowel Disease and Neurodegenerative Diseases
title_full_unstemmed Inflammatory Bowel Disease and Neurodegenerative Diseases
title_short Inflammatory Bowel Disease and Neurodegenerative Diseases
title_sort inflammatory bowel disease and neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352055/
https://www.ncbi.nlm.nih.gov/pubmed/36843420
http://dx.doi.org/10.5009/gnl220523
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