Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination

Multiple factors, including vaccine platform and prior vaccinations, influence vaccine responses. We compared antibody responses to CoronaVac (Sinovac) and ChAdOx1-S (AstraZeneca-Oxford) vaccination in 874 healthcare workers in Brazil. As participants were randomised to BCG vaccination or placebo in...

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Autores principales: Messina, Nicole L., Sperotto, Mariana G., Puga, Marco A. M., da Silva, Patricia V., de Oliveira, Roberto D., Moore, Cecilia L., Pittet, Laure F., Jamieson, Tenaya, Dalcolmo, Margareth, dos Santos, Glauce, Jardim, Bruno, Lacerda, Marcus V. G., Curtis, Nigel, Croda, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352084/
https://www.ncbi.nlm.nih.gov/pubmed/37465688
http://dx.doi.org/10.3389/fimmu.2023.1172851
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author Messina, Nicole L.
Sperotto, Mariana G.
Puga, Marco A. M.
da Silva, Patricia V.
de Oliveira, Roberto D.
Moore, Cecilia L.
Pittet, Laure F.
Jamieson, Tenaya
Dalcolmo, Margareth
dos Santos, Glauce
Jardim, Bruno
Lacerda, Marcus V. G.
Curtis, Nigel
Croda, Julio
author_facet Messina, Nicole L.
Sperotto, Mariana G.
Puga, Marco A. M.
da Silva, Patricia V.
de Oliveira, Roberto D.
Moore, Cecilia L.
Pittet, Laure F.
Jamieson, Tenaya
Dalcolmo, Margareth
dos Santos, Glauce
Jardim, Bruno
Lacerda, Marcus V. G.
Curtis, Nigel
Croda, Julio
author_sort Messina, Nicole L.
collection PubMed
description Multiple factors, including vaccine platform and prior vaccinations, influence vaccine responses. We compared antibody responses to CoronaVac (Sinovac) and ChAdOx1-S (AstraZeneca-Oxford) vaccination in 874 healthcare workers in Brazil. As participants were randomised to BCG vaccination or placebo in the preceding 0-6 months as part of the BCG vaccination to reduce the impact of COVID-19 in healthcare workers (BRACE) trial, we also investigated the influence of recent BCG vaccination on antibody responses to these COVID-19 vaccines. Twenty-eight days after the second dose of each vaccine, ChAdOx1-S induced a stronger anti-spike IgG response than CoronaVac vaccination. Recent BCG vaccination did not impact IgG antibody responses to ChAdOx1-S or CoronaVac.
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spelling pubmed-103520842023-07-18 Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination Messina, Nicole L. Sperotto, Mariana G. Puga, Marco A. M. da Silva, Patricia V. de Oliveira, Roberto D. Moore, Cecilia L. Pittet, Laure F. Jamieson, Tenaya Dalcolmo, Margareth dos Santos, Glauce Jardim, Bruno Lacerda, Marcus V. G. Curtis, Nigel Croda, Julio Front Immunol Immunology Multiple factors, including vaccine platform and prior vaccinations, influence vaccine responses. We compared antibody responses to CoronaVac (Sinovac) and ChAdOx1-S (AstraZeneca-Oxford) vaccination in 874 healthcare workers in Brazil. As participants were randomised to BCG vaccination or placebo in the preceding 0-6 months as part of the BCG vaccination to reduce the impact of COVID-19 in healthcare workers (BRACE) trial, we also investigated the influence of recent BCG vaccination on antibody responses to these COVID-19 vaccines. Twenty-eight days after the second dose of each vaccine, ChAdOx1-S induced a stronger anti-spike IgG response than CoronaVac vaccination. Recent BCG vaccination did not impact IgG antibody responses to ChAdOx1-S or CoronaVac. Frontiers Media S.A. 2023-07-03 /pmc/articles/PMC10352084/ /pubmed/37465688 http://dx.doi.org/10.3389/fimmu.2023.1172851 Text en Copyright © 2023 Messina, Sperotto, Puga, da Silva, de Oliveira, Moore, Pittet, Jamieson, Dalcolmo, dos Santos, Jardim, Lacerda, Curtis and Croda https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Messina, Nicole L.
Sperotto, Mariana G.
Puga, Marco A. M.
da Silva, Patricia V.
de Oliveira, Roberto D.
Moore, Cecilia L.
Pittet, Laure F.
Jamieson, Tenaya
Dalcolmo, Margareth
dos Santos, Glauce
Jardim, Bruno
Lacerda, Marcus V. G.
Curtis, Nigel
Croda, Julio
Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination
title Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination
title_full Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination
title_fullStr Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination
title_full_unstemmed Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination
title_short Impact of vaccine platform and BCG vaccination on antibody responses to COVID-19 vaccination
title_sort impact of vaccine platform and bcg vaccination on antibody responses to covid-19 vaccination
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352084/
https://www.ncbi.nlm.nih.gov/pubmed/37465688
http://dx.doi.org/10.3389/fimmu.2023.1172851
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