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A Retrospective Cohort Study on the Prevalence, Risk Factors, and Improvement of Overactive Bladder Symptoms in Women with Pelvic Organ Prolapse

BACKGROUND: Overactive bladder (OAB) symptoms are common in women with pelvic organ prolapse (POP), but the explanation is unclear. It is also uncertain whether OAB symptoms improve or persist after POP reduction. This study aimed to determine the prevalence and risk factors for OAB symptoms in wome...

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Autores principales: Aimjirakul, Komkrit, Ng, Jun Jiet, Saraluck, Apisith, Wattanayingcharoenchai, Rujira, Mangmeesri, Peeranuch, Manonai, Jittima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352122/
https://www.ncbi.nlm.nih.gov/pubmed/37469654
http://dx.doi.org/10.2147/IJWH.S413670
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author Aimjirakul, Komkrit
Ng, Jun Jiet
Saraluck, Apisith
Wattanayingcharoenchai, Rujira
Mangmeesri, Peeranuch
Manonai, Jittima
author_facet Aimjirakul, Komkrit
Ng, Jun Jiet
Saraluck, Apisith
Wattanayingcharoenchai, Rujira
Mangmeesri, Peeranuch
Manonai, Jittima
author_sort Aimjirakul, Komkrit
collection PubMed
description BACKGROUND: Overactive bladder (OAB) symptoms are common in women with pelvic organ prolapse (POP), but the explanation is unclear. It is also uncertain whether OAB symptoms improve or persist after POP reduction. This study aimed to determine the prevalence and risk factors for OAB symptoms in women with POP, and to compare the improvement of OAB symptoms among women in three treatment groups: pelvic floor exercise, pessary, and surgery. METHODS: This retrospective cohort study included patients who visited our urogynecology clinic from January 2016 to December 2020. The Pelvic Floor Bother Questionnaire was used to evaluate selected pelvic floor symptoms (OAB and POP). Demographic characteristics and clinical findings, including Pelvic Organ Prolapse Quantification System and number of prolapsed compartments, were analyzed. Univariate and multivariate analyses were conducted to identify risk factors for OAB symptoms in women with POP. Subgroup analyses were performed in 533 patients to evaluate the improvement of OAB symptoms following POP treatment. RESULTS: A total of 754 patients were analyzed. The incidence of OAB symptoms was 70% (533/754) and two-thirds (65%) reported moderate to severe bother. The lowest points of the anterior wall (OR 0.60; 95% CI 0.41–0.87; p = 0.01), longer perineal body (OR 0.78; 95% CI 0.21–0.76; p = 0.02), and previous vaginal delivery (OR 2.10; 95% CI 1.14–3.89; p = 0.02) were identified as significant risk factors. In the subgroup analyses, improvement in OAB symptoms was observed in 36.6% (195/533) of women who underwent POP treatment. Compared with pelvic floor exercise, pessary (OR 1.40; 95% CI 0.94–2.07; p = 0.10) and surgery (OR 1.30; 95% CI 0.80–2.12; p = 0.28) had higher odd ratios but the effects were not significant. CONCLUSION: The prevalence of OAB symptoms in women with POP was high at 70%. Improvement in OAB symptoms was observed in one-third of women who underwent POP treatment. However, there were no significant differences between the treatment methods.
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spelling pubmed-103521222023-07-19 A Retrospective Cohort Study on the Prevalence, Risk Factors, and Improvement of Overactive Bladder Symptoms in Women with Pelvic Organ Prolapse Aimjirakul, Komkrit Ng, Jun Jiet Saraluck, Apisith Wattanayingcharoenchai, Rujira Mangmeesri, Peeranuch Manonai, Jittima Int J Womens Health Original Research BACKGROUND: Overactive bladder (OAB) symptoms are common in women with pelvic organ prolapse (POP), but the explanation is unclear. It is also uncertain whether OAB symptoms improve or persist after POP reduction. This study aimed to determine the prevalence and risk factors for OAB symptoms in women with POP, and to compare the improvement of OAB symptoms among women in three treatment groups: pelvic floor exercise, pessary, and surgery. METHODS: This retrospective cohort study included patients who visited our urogynecology clinic from January 2016 to December 2020. The Pelvic Floor Bother Questionnaire was used to evaluate selected pelvic floor symptoms (OAB and POP). Demographic characteristics and clinical findings, including Pelvic Organ Prolapse Quantification System and number of prolapsed compartments, were analyzed. Univariate and multivariate analyses were conducted to identify risk factors for OAB symptoms in women with POP. Subgroup analyses were performed in 533 patients to evaluate the improvement of OAB symptoms following POP treatment. RESULTS: A total of 754 patients were analyzed. The incidence of OAB symptoms was 70% (533/754) and two-thirds (65%) reported moderate to severe bother. The lowest points of the anterior wall (OR 0.60; 95% CI 0.41–0.87; p = 0.01), longer perineal body (OR 0.78; 95% CI 0.21–0.76; p = 0.02), and previous vaginal delivery (OR 2.10; 95% CI 1.14–3.89; p = 0.02) were identified as significant risk factors. In the subgroup analyses, improvement in OAB symptoms was observed in 36.6% (195/533) of women who underwent POP treatment. Compared with pelvic floor exercise, pessary (OR 1.40; 95% CI 0.94–2.07; p = 0.10) and surgery (OR 1.30; 95% CI 0.80–2.12; p = 0.28) had higher odd ratios but the effects were not significant. CONCLUSION: The prevalence of OAB symptoms in women with POP was high at 70%. Improvement in OAB symptoms was observed in one-third of women who underwent POP treatment. However, there were no significant differences between the treatment methods. Dove 2023-07-13 /pmc/articles/PMC10352122/ /pubmed/37469654 http://dx.doi.org/10.2147/IJWH.S413670 Text en © 2023 Aimjirakul et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Aimjirakul, Komkrit
Ng, Jun Jiet
Saraluck, Apisith
Wattanayingcharoenchai, Rujira
Mangmeesri, Peeranuch
Manonai, Jittima
A Retrospective Cohort Study on the Prevalence, Risk Factors, and Improvement of Overactive Bladder Symptoms in Women with Pelvic Organ Prolapse
title A Retrospective Cohort Study on the Prevalence, Risk Factors, and Improvement of Overactive Bladder Symptoms in Women with Pelvic Organ Prolapse
title_full A Retrospective Cohort Study on the Prevalence, Risk Factors, and Improvement of Overactive Bladder Symptoms in Women with Pelvic Organ Prolapse
title_fullStr A Retrospective Cohort Study on the Prevalence, Risk Factors, and Improvement of Overactive Bladder Symptoms in Women with Pelvic Organ Prolapse
title_full_unstemmed A Retrospective Cohort Study on the Prevalence, Risk Factors, and Improvement of Overactive Bladder Symptoms in Women with Pelvic Organ Prolapse
title_short A Retrospective Cohort Study on the Prevalence, Risk Factors, and Improvement of Overactive Bladder Symptoms in Women with Pelvic Organ Prolapse
title_sort retrospective cohort study on the prevalence, risk factors, and improvement of overactive bladder symptoms in women with pelvic organ prolapse
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352122/
https://www.ncbi.nlm.nih.gov/pubmed/37469654
http://dx.doi.org/10.2147/IJWH.S413670
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