Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation

Zygotic genome activation (ZGA) is essential for early embryonic development. However, the regulation of ZGA remains elusive in mammals. Here we report that a maternal factor TDP-43, a nuclear transactive response DNA-binding protein, regulates ZGA through RNA Pol II and is essential for mouse early...

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Detalles Bibliográficos
Autores principales: Nie, Xiaoqing, Xu, Qianhua, Xu, Chengpeng, Chen, Fengling, Wang, Qizhi, Qin, Dandan, Wang, Rui, Gao, Zheng, Lu, Xukun, Yang, Xinai, Wu, Yu, Gu, Chen, Xie, Wei, Li, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352294/
https://www.ncbi.nlm.nih.gov/pubmed/37460529
http://dx.doi.org/10.1038/s41467-023-39924-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352294/
https://www.ncbi.nlm.nih.gov/pubmed/37460529
http://dx.doi.org/10.1038/s41467-023-39924-1

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