Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy

Introduction: There is a major societal need for analgesics with less tolerance, dependence, and abuse liability. Preclinical rodent studies suggest that bifunctional ligands with both mu (MOPr) and delta (DOPr) opioid peptide receptor activity may produce analgesia with reduced tolerance and other...

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Detalles Bibliográficos
Autores principales: Olson, Keith M., Devereaux, Andrea L., Chatterjee, Payal, Saldaña-Shumaker, Savanah L., Shafer, Amanda, Plotkin, Adam, Kandasamy, Ram, MacKerell, Alexander D., Traynor, John R., Cunningham, Christopher W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352325/
https://www.ncbi.nlm.nih.gov/pubmed/37469877
http://dx.doi.org/10.3389/fphar.2023.1230053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352325/
https://www.ncbi.nlm.nih.gov/pubmed/37469877
http://dx.doi.org/10.3389/fphar.2023.1230053

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