IL1R1(+) cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer

Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1(+), IL-1-high-signaling subtype of fibroblasts, using multiple colorectal cancer (CRC) patient single cell sequencing datasets. Th...

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Detalles Bibliográficos
Autores principales: Koncina, E., Nurmik, M., Pozdeev, V. I., Gilson, C., Tsenkova, M., Begaj, R., Stang, S., Gaigneaux, A., Weindorfer, C., Rodriguez, F., Schmoetten, M., Klein, E., Karta, J., Atanasova, V. S., Grzyb, K., Ullmann, P., Halder, R., Hengstschläger, M., Graas, J., Augendre, V., Karapetyan, Y. E., Kerger, L., Zuegel, N., Skupin, A., Haan, S., Meiser, J., Dolznig, H., Letellier, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352362/
https://www.ncbi.nlm.nih.gov/pubmed/37460545
http://dx.doi.org/10.1038/s41467-023-39953-w

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