Isolation of Hafnia paralvei co-harbouring bla(NDM-1) and bla(VIM-1) in a woman who underwent allogeneic hematopoietic stem cell transplantation

Metallo-β-lactamases (MBL) are a threat to public health, since they dramatically limit the use of β-lactams. We report the isolation of a multidrug-resistant Hafnia paralvei strain from urine and a rectal swab of a female patient after allogeneic hematopoietic stem cell transplantation for myelodys...

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Autores principales: Appel, Tobias Manuel, Stein, Claudia, Brandt, Christian, Rödel, Jürgen, Frietsch, Jochen J., Miethke, Jenny, Hochhaus, Andreas, Hilgendorf, Inken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352390/
https://www.ncbi.nlm.nih.gov/pubmed/36595211
http://dx.doi.org/10.1007/s15010-022-01976-8
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author Appel, Tobias Manuel
Stein, Claudia
Brandt, Christian
Rödel, Jürgen
Frietsch, Jochen J.
Miethke, Jenny
Hochhaus, Andreas
Hilgendorf, Inken
author_facet Appel, Tobias Manuel
Stein, Claudia
Brandt, Christian
Rödel, Jürgen
Frietsch, Jochen J.
Miethke, Jenny
Hochhaus, Andreas
Hilgendorf, Inken
author_sort Appel, Tobias Manuel
collection PubMed
description Metallo-β-lactamases (MBL) are a threat to public health, since they dramatically limit the use of β-lactams. We report the isolation of a multidrug-resistant Hafnia paralvei strain from urine and a rectal swab of a female patient after allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome. Antimicrobial susceptibility testing yielded resistance to trimethoprim/sulfamethoxazole, colistin, fosfomycin and all β-lactams, except cefiderocol. Whole genome sequencing revealed the presence of plasmid-encoded NDM-1 and VIM-1 carbapenemases. This finding highlights the importance of epidemiological surveillance and new therapeutic options for MBL.
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spelling pubmed-103523902023-07-19 Isolation of Hafnia paralvei co-harbouring bla(NDM-1) and bla(VIM-1) in a woman who underwent allogeneic hematopoietic stem cell transplantation Appel, Tobias Manuel Stein, Claudia Brandt, Christian Rödel, Jürgen Frietsch, Jochen J. Miethke, Jenny Hochhaus, Andreas Hilgendorf, Inken Infection Case Report Metallo-β-lactamases (MBL) are a threat to public health, since they dramatically limit the use of β-lactams. We report the isolation of a multidrug-resistant Hafnia paralvei strain from urine and a rectal swab of a female patient after allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome. Antimicrobial susceptibility testing yielded resistance to trimethoprim/sulfamethoxazole, colistin, fosfomycin and all β-lactams, except cefiderocol. Whole genome sequencing revealed the presence of plasmid-encoded NDM-1 and VIM-1 carbapenemases. This finding highlights the importance of epidemiological surveillance and new therapeutic options for MBL. Springer Berlin Heidelberg 2023-01-03 2023 /pmc/articles/PMC10352390/ /pubmed/36595211 http://dx.doi.org/10.1007/s15010-022-01976-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Appel, Tobias Manuel
Stein, Claudia
Brandt, Christian
Rödel, Jürgen
Frietsch, Jochen J.
Miethke, Jenny
Hochhaus, Andreas
Hilgendorf, Inken
Isolation of Hafnia paralvei co-harbouring bla(NDM-1) and bla(VIM-1) in a woman who underwent allogeneic hematopoietic stem cell transplantation
title Isolation of Hafnia paralvei co-harbouring bla(NDM-1) and bla(VIM-1) in a woman who underwent allogeneic hematopoietic stem cell transplantation
title_full Isolation of Hafnia paralvei co-harbouring bla(NDM-1) and bla(VIM-1) in a woman who underwent allogeneic hematopoietic stem cell transplantation
title_fullStr Isolation of Hafnia paralvei co-harbouring bla(NDM-1) and bla(VIM-1) in a woman who underwent allogeneic hematopoietic stem cell transplantation
title_full_unstemmed Isolation of Hafnia paralvei co-harbouring bla(NDM-1) and bla(VIM-1) in a woman who underwent allogeneic hematopoietic stem cell transplantation
title_short Isolation of Hafnia paralvei co-harbouring bla(NDM-1) and bla(VIM-1) in a woman who underwent allogeneic hematopoietic stem cell transplantation
title_sort isolation of hafnia paralvei co-harbouring bla(ndm-1) and bla(vim-1) in a woman who underwent allogeneic hematopoietic stem cell transplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352390/
https://www.ncbi.nlm.nih.gov/pubmed/36595211
http://dx.doi.org/10.1007/s15010-022-01976-8
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