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An integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research
Life course epidemiology seeks to understand the intricate relationships between risk factors and health outcomes across different stages of life to inform prevention and intervention strategies to optimize health throughout the lifespan. However, extant evidence has predominantly been based on sepa...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352429/ https://www.ncbi.nlm.nih.gov/pubmed/37469576 http://dx.doi.org/10.1007/s44155-023-00044-2 |
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author | Zuber, Sascha Bechtiger, Laura Bodelet, Julien Stéphane Golin, Marta Heumann, Jens Kim, Jung Hyun Klee, Matthias Mur, Jure Noll, Jennie Voll, Stacey O’Keefe, Patrick Steinhoff, Annekatrin Zölitz, Ulf Muniz-Terrera, Graciela Shanahan, Lilly Shanahan, Michael J. Hofer, Scott M. |
author_facet | Zuber, Sascha Bechtiger, Laura Bodelet, Julien Stéphane Golin, Marta Heumann, Jens Kim, Jung Hyun Klee, Matthias Mur, Jure Noll, Jennie Voll, Stacey O’Keefe, Patrick Steinhoff, Annekatrin Zölitz, Ulf Muniz-Terrera, Graciela Shanahan, Lilly Shanahan, Michael J. Hofer, Scott M. |
author_sort | Zuber, Sascha |
collection | PubMed |
description | Life course epidemiology seeks to understand the intricate relationships between risk factors and health outcomes across different stages of life to inform prevention and intervention strategies to optimize health throughout the lifespan. However, extant evidence has predominantly been based on separate analyses of data from individual birth cohorts or panel studies, which may not be sufficient to unravel the complex interplay of risk and health across different contexts. We highlight the importance of a multi-study perspective that enables researchers to: (a) Compare and contrast findings from different contexts and populations, which can help identify generalizable patterns and context-specific factors; (b) Examine the robustness of associations and the potential for effect modification by factors such as age, sex, and socioeconomic status; and (c) Improve statistical power and precision by pooling data from multiple studies, thereby allowing for the investigation of rare exposures and outcomes. This integrative framework combines the advantages of multi-study data with a life course perspective to guide research in understanding life course risk and resilience on adult health outcomes by: (a) Encouraging the use of harmonized measures across studies to facilitate comparisons and synthesis of findings; (b) Promoting the adoption of advanced analytical techniques that can accommodate the complexities of multi-study, longitudinal data; and (c) Fostering collaboration between researchers, data repositories, and funding agencies to support the integration of longitudinal data from diverse sources. An integrative approach can help inform the development of individualized risk scores and personalized interventions to promote health and well-being at various life stages. |
format | Online Article Text |
id | pubmed-10352429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-103524292023-07-19 An integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research Zuber, Sascha Bechtiger, Laura Bodelet, Julien Stéphane Golin, Marta Heumann, Jens Kim, Jung Hyun Klee, Matthias Mur, Jure Noll, Jennie Voll, Stacey O’Keefe, Patrick Steinhoff, Annekatrin Zölitz, Ulf Muniz-Terrera, Graciela Shanahan, Lilly Shanahan, Michael J. Hofer, Scott M. Discov Soc Sci Health Perspective Life course epidemiology seeks to understand the intricate relationships between risk factors and health outcomes across different stages of life to inform prevention and intervention strategies to optimize health throughout the lifespan. However, extant evidence has predominantly been based on separate analyses of data from individual birth cohorts or panel studies, which may not be sufficient to unravel the complex interplay of risk and health across different contexts. We highlight the importance of a multi-study perspective that enables researchers to: (a) Compare and contrast findings from different contexts and populations, which can help identify generalizable patterns and context-specific factors; (b) Examine the robustness of associations and the potential for effect modification by factors such as age, sex, and socioeconomic status; and (c) Improve statistical power and precision by pooling data from multiple studies, thereby allowing for the investigation of rare exposures and outcomes. This integrative framework combines the advantages of multi-study data with a life course perspective to guide research in understanding life course risk and resilience on adult health outcomes by: (a) Encouraging the use of harmonized measures across studies to facilitate comparisons and synthesis of findings; (b) Promoting the adoption of advanced analytical techniques that can accommodate the complexities of multi-study, longitudinal data; and (c) Fostering collaboration between researchers, data repositories, and funding agencies to support the integration of longitudinal data from diverse sources. An integrative approach can help inform the development of individualized risk scores and personalized interventions to promote health and well-being at various life stages. Springer International Publishing 2023-07-17 2023 /pmc/articles/PMC10352429/ /pubmed/37469576 http://dx.doi.org/10.1007/s44155-023-00044-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Perspective Zuber, Sascha Bechtiger, Laura Bodelet, Julien Stéphane Golin, Marta Heumann, Jens Kim, Jung Hyun Klee, Matthias Mur, Jure Noll, Jennie Voll, Stacey O’Keefe, Patrick Steinhoff, Annekatrin Zölitz, Ulf Muniz-Terrera, Graciela Shanahan, Lilly Shanahan, Michael J. Hofer, Scott M. An integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research |
title | An integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research |
title_full | An integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research |
title_fullStr | An integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research |
title_full_unstemmed | An integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research |
title_short | An integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research |
title_sort | integrative approach for the analysis of risk and health across the life course: challenges, innovations, and opportunities for life course research |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352429/ https://www.ncbi.nlm.nih.gov/pubmed/37469576 http://dx.doi.org/10.1007/s44155-023-00044-2 |
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