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Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging

Macrophages adapt distinct pro‐inflammatory (M1‐like) and pro‐resolving (M2‐like) phenotypes with specific tasks in the immune response and tissue homeostasis. Altered macrophage responses with age are causative for unresolved inflammation, so‐called inflammaging, and lead to higher infection suscep...

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Detalles Bibliográficos
Autores principales: Schädel, Patrick, Czapka, Anna, Gebert, Nadja, Jacobsen, Ilse Denise, Ori, Alessandro, Werz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352559/
https://www.ncbi.nlm.nih.gov/pubmed/37101405
http://dx.doi.org/10.1111/acel.13856