GM‐CSF and IL‐7 fusion cytokine engineered tumor vaccine generates long‐term Th‐17 memory cells and increases overall survival in aged syngeneic mouse models of glioblastoma

Age‐related immune dysfunctions, such as decreased T‐cell output, are closely related to pathologies like cancers and lack of vaccine efficacy among the elderly. Engineered fusokine, GIFT‐7, a fusion of interleukin 7 (IL‐7) and GM‐CSF, can reverse aging‐related lymphoid organ atrophy. We generated a...

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Detalles Bibliográficos
Autores principales: Shireman, Jack M., Gonugunta, Nikita, Zhao, Lei, Pattnaik, Akshita, Distler, Emily, Her, Skyler, Wang, Xiaohu, Das, Rahul, Galipeau, Jaques, Dey, Mahua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352573/
https://www.ncbi.nlm.nih.gov/pubmed/37165998
http://dx.doi.org/10.1111/acel.13864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352573/
https://www.ncbi.nlm.nih.gov/pubmed/37165998
http://dx.doi.org/10.1111/acel.13864

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