Cargando…

GM‐CSF and IL‐7 fusion cytokine engineered tumor vaccine generates long‐term Th‐17 memory cells and increases overall survival in aged syngeneic mouse models of glioblastoma

Age‐related immune dysfunctions, such as decreased T‐cell output, are closely related to pathologies like cancers and lack of vaccine efficacy among the elderly. Engineered fusokine, GIFT‐7, a fusion of interleukin 7 (IL‐7) and GM‐CSF, can reverse aging‐related lymphoid organ atrophy. We generated a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shireman, Jack M., Gonugunta, Nikita, Zhao, Lei, Pattnaik, Akshita, Distler, Emily, Her, Skyler, Wang, Xiaohu, Das, Rahul, Galipeau, Jaques, Dey, Mahua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352573/ https://www.ncbi.nlm.nih.gov/pubmed/37165998 http://dx.doi.org/10.1111/acel.13864

Ejemplares similares

Sexual dimorphism of the immune system predicts clinical outcomes in glioblastoma immunotherapy: A systematic review and meta-analysis
por: Shireman, Jack M, et al.
Publicado: (2022)

Reduced expression of FRG1 facilitates breast cancer progression via GM-CSF/MEK-ERK axis by abating FRG1 mediated transcriptional repression of GM-CSF
por: Mukherjee, Bratati, et al.
Publicado: (2022)

GM-CSF in inflammation
por: Hamilton, John A.
Publicado: (2019)

Use of syngeneic cells expressing membrane-bound GM-CSF as an adjuvant to induce antibodies against native multi-pass transmembrane protein
por: Huang, Chien-Chiao, et al.
Publicado: (2019)

G-CSF and GM-CSF in clinical trials.
por: Antman, K. H.
Publicado: (1990)

Recombinant GM-CSF for diseases of GM-CSF insufficiency: Correcting dysfunctional mononuclear phagocyte disorders
por: Lazarus, Hillard M., et al.
Publicado: (2023)

Genomic Analysis of Human Brain Metastases Treated with Stereotactic Radiosurgery Under the Phase-II Clinical Trial (NCT03398694) Reveals DNA Damage Repair at the Peripheral Tumor Edge
por: Shireman, Jack M., et al.
Publicado: (2023)

A role for G-CSF and GM-CSF in nonmyeloid cancers
por: Aliper, Alexander M, et al.
Publicado: (2014)

GM-CSF-Dependent Inflammatory Pathways
por: Hamilton, John A.
Publicado: (2019)

Development of Dendritic Cells from GM-CSF(-/-) Mice in vitro : GM-CSF Enhances Production and Survival of Cells
por: Ni, Keping, et al.
Publicado: (2001)

Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough?
por: Shireman, Jack M., et al.
Publicado: (2023)

Response to Treatment with TNFα Inhibitors in Rheumatoid Arthritis Is Associated with High Levels of GM-CSF and GM-CSF(+) T Lymphocytes
por: Bystrom, Jonas, et al.
Publicado: (2017)

Construction of Recombinant Human GM-CSF and GM-CSF-ApoA-I Fusion Protein and Evaluation of Their Biological Activity
por: Pykhtina, Mariya, et al.
Publicado: (2021)

Pivotal Roles of GM-CSF in Autoimmunity and Inflammation
por: Shiomi, Aoi, et al.
Publicado: (2015)

A Review of GM-CSF Therapy in Sepsis
por: Mathias, Brittany, et al.
Publicado: (2015)

The efficacy and safety of targeting GM-CSF in arthritis
por: Bykerk, Vivian P
Publicado: (2020)

GM-CSF: Orchestrating the Pulmonary Response to Infection
por: McCormick, Thomas S., et al.
Publicado: (2022)

Role of GM-CSF in lung balance and disease
por: Chen, Yingzi, et al.
Publicado: (2023)

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment
por: Bosteels, Cedric, et al.
Publicado: (2022)

G‐CSF/GM‐CSF‐induced hematopoietic dysregulation in the progression of solid tumors
por: He, Kai, et al.
Publicado: (2022)

Selective, high-contrast detection of syngeneic glioblastoma in vivo
por: Banati, Richard B., et al.
Publicado: (2020)

Neoadjuvant anti-PD-1 immunotherapy for recurrent glioblastoma
por: Mitchell, Dana, et al.
Publicado: (2019)

G-CSF and GM-CSF Modify Neutrophil Functions at Concentrations found in Cystic Fibrosis
por: Castellani, Stefano, et al.
Publicado: (2019)

Functional characterization of GM-CSF induced monocyte subsets
por: Däbritz, J, et al.
Publicado: (2008)

Delivery of GM-CSF to Protect against Influenza Pneumonia
por: Subramaniam, Renuka, et al.
Publicado: (2015)

GM-CSF as a therapeutic target in autoimmune diseases
por: Shiomi, Aoi, et al.
Publicado: (2016)

Roles of GM-CSF in the Pathogenesis of Autoimmune Diseases: An Update
por: Lotfi, Noushin, et al.
Publicado: (2019)

GM-CSF: A Promising Target in Inflammation and Autoimmunity
por: Lee, Kevin M C, et al.
Publicado: (2020)

GM-CSF Dependent Differential Control of Mycobacterium tuberculosis Infection in Human and Mouse Macrophages: Is Macrophage Source of GM-CSF Critical to Tuberculosis Immunity?
por: Mishra, Abhishek, et al.
Publicado: (2020)

Glutamine Deprivation Promotes the Generation and Mobilization of MDSCs by Enhancing Expression of G-CSF and GM-CSF
por: Sun, Hong-Wei, et al.
Publicado: (2021)

Exposure to inflammatory cytokines selectively limits GM-CSF production by induced T regulatory cells
por: Reynolds, Ben C, et al.
Publicado: (2014)

GM-CSF in the treatment of COVID-19: a new conductor in the pathogenesis of cytokine storm?
por: Favalli, Ennio Giulio, et al.
Publicado: (2020)

RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines
por: Shang, Siqi, et al.
Publicado: (2023)

Determinants of a transcriptionally competent environment at the GM-CSF promoter
por: Brettingham-Moore, K. H., et al.
Publicado: (2008)

Retrovirus mediated transfer and expression of GM-CSF in haematopoietic cells.
por: Keith, W. N., et al.
Publicado: (1990)

Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer
por: Enzler, Thomas, et al.
Publicado: (2003)

GM-CSF Signalling Boosts Dramatically IL-1Production
por: Khameneh, Hanif Javanmard, et al.
Publicado: (2011)

Clinical uses of GM-CSF, a critical appraisal and update
por: Arellano, Martha, et al.
Publicado: (2008)

GM-CSF facilitates the development of inflammation-associated colorectal carcinoma
por: Chen, Guojiang, et al.
Publicado: (2014)

Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis
por: Piccoli, Luca, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hgcgfncrrtmu0dvasg4un9n9jn