Cargando…

Structure of coagulation factor VIII bound to a patient-derived anti–C1 domain antibody inhibitor

The development of pathogenic antibody inhibitors against coagulation factor VIII (FVIII) occurs in ∼30% of patients with congenital hemophilia A receiving FVIII replacement therapy, as well as in all cases of acquired hemophilia A. KM33 is an anti–C1 domain antibody inhibitor previously isolated fr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Childers, Kenneth C., Avery, Nathan G., Estrada Alamo, Kevin A., Davulcu, Omar, Haynes, Rose Marie, Lollar, Pete, Doering, Christopher B., Coxon, Carmen H., Spiegel, P. Clint
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Thrombosis and Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352601/ https://www.ncbi.nlm.nih.gov/pubmed/37192299 http://dx.doi.org/10.1182/blood.2023020181

Ejemplares similares

SAXS analysis of the intrinsic tenase complex bound to a lipid nanodisc highlights intermolecular contacts between factors VIIIa/IXa
por: Childers, Kenneth C., et al.
Publicado: (2022)

Mechano-covalent protection of coagulation factor VIII by von Willebrand factor
por: Butera, Diego, et al.
Publicado: (2022)

Influence of N-glycosylation in the A and C domains on the immunogenicity of factor VIII
por: Vander Kooi, Amber, et al.
Publicado: (2022)

Cryo-EM structure of coagulation factor V short
por: Mohammed, Bassem M., et al.
Publicado: (2023)

Factor VIII trafficking to CD4(+) T cells shapes its immunogenicity and requires several types of antigen-presenting cells
por: Kaczmarek, Radoslaw, et al.
Publicado: (2023)

von Willebrand factor modulates immune complexes and the recall response against factor VIII in a murine hemophilia A model
por: Oleshko, Olga, et al.
Publicado: (2023)

Lower-leg injury and knee arthroscopy have distinct effects on coagulation
por: Touw, Carolina E., et al.
Publicado: (2022)

Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation
por: Parunov, Leonid A., et al.
Publicado: (2023)

Tissue factor activates the coagulation cascade in mouse models of acute promyelocytic leukemia
por: Hisada, Yohei, et al.
Publicado: (2023)

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection
por: Al-Samkari, Hanny, et al.
Publicado: (2020)

Role of ribosomal RNA released from red cells in blood coagulation in zebrafish and humans
por: Alharbi, Abdulmajeed, et al.
Publicado: (2021)

Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19
por: Henderson, Michael W., et al.
Publicado: (2022)

A novel mouse whole blood thrombin generation assay sensitive to FXI- and FIX-mediated amplification of coagulation
por: Wan, Jun, et al.
Publicado: (2022)

Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains
por: Shamanaev, Aleksandr, et al.
Publicado: (2022)

A conformational transition of the D′D3 domain primes von Willebrand factor for multimerization
por: Gruber, Sophia, et al.
Publicado: (2022)

The interplay between tissue plasminogen activator domains and fibrin structures in the regulation of fibrinolysis: kinetic and microscopic studies
por: Longstaff, Colin, et al.
Publicado: (2011)

Assembly of von Willebrand factor tubules with in vivo helical parameters requires A1 domain insertion
por: Javitt, Gabriel, et al.
Publicado: (2022)

Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain
por: Andersson, Helena M., et al.
Publicado: (2010)

Structure of Blood Coagulation Factor VIII in Complex With an Anti-C2 Domain Non-Classical, Pathogenic Antibody Inhibitor
por: Ronayne, Estelle K., et al.
Publicado: (2021)

Fibrin protofibril packing and clot stability are enhanced by extended knob-hole interactions and catch-slip bonds
por: Asquith, Nathan L., et al.
Publicado: (2022)

Harmful or Physiologic: Diagnosing Fibrinolysis Shutdown in a Trauma Cohort With Rotational Thromboelastometry
por: Gomez-Builes, J. Carolina, et al.
Publicado: (2018)

Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury
por: Bain, William, et al.
Publicado: (2019)

Targeting complement activation in COVID-19
por: Kulkarni, Hrishikesh S., et al.
Publicado: (2020)

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
por: Yu, Jia, et al.
Publicado: (2020)

COVID-19 coagulopathy, thrombosis, and bleeding
por: Chan, Noel C., et al.
Publicado: (2020)

Frequency of venous thromboembolism in 6513 patients with COVID-19: a retrospective study
por: Hill, Jason B., et al.
Publicado: (2020)

A toolkit for the collection of thrombosis-related data elements in COVID-19 clinical studies
por: Siegal, Deborah M., et al.
Publicado: (2020)

Incidence of symptomatic, image-confirmed venous thromboembolism following hospitalization for COVID-19 with 90-day follow-up
por: Salisbury, Richard, et al.
Publicado: (2020)

Postdischarge thromboembolic outcomes and mortality of hospitalized patients with COVID-19: the CORE-19 registry
por: Giannis, Dimitrios, et al.
Publicado: (2021)

A factor VIIIa–mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice
por: Østergaard, Henrik, et al.
Publicado: (2021)

COVID-19 and VITT: same or different?
por: Arepally, Gowthami M.
Publicado: (2021)

von Willebrand factor antigen levels are associated with burden of rare nonsynonymous variants in the VWF gene
por: Sadler, Brooke, et al.
Publicado: (2021)

An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function
por: Pijning, Aster E., et al.
Publicado: (2021)

Novel mechanism regulating tissue factor activity
por: Nieuwland, Rienk
Publicado: (2021)

The incidence of cancer-associated thrombosis is increasing over time
por: Mahajan, Anjlee, et al.
Publicado: (2022)

The binding of autotaxin to integrins mediates hyperhomocysteinemia-potentiated platelet activation and thrombosis in mice and humans
por: Han, Lulu, et al.
Publicado: (2021)

Polyphosphate expression by cancer cell extracellular vesicles mediates binding of factor XII and contact activation
por: Shim, Young Jun, et al.
Publicado: (2021)

Most anti-PF4 antibodies in vaccine-induced immune thrombotic thrombocytopenia are transient
por: Schönborn, Linda, et al.
Publicado: (2022)

PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke
por: Dhanesha, Nirav, et al.
Publicado: (2022)

Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
por: Wygrecka, Malgorzata, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_26j2n25fa32hcbi0fran2iif18