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Do macrophages follow the beat of circadian rhythm in TIME (Tumor Immune Microenvironment)?

Advances in cancer research have made clear the critical role of the immune response in clearing tumors. This breakthrough in scientific understanding was heralded by the success of immune checkpoint blockade (ICB) therapies such as anti-programmed cell death protein 1 (PD-1)/ programmed death-ligan...

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Autores principales: Knudsen-Clark, Amelia M., Cazarin, Juliana, Altman, Brian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352629/
https://www.ncbi.nlm.nih.gov/pubmed/37469718
http://dx.doi.org/10.12688/f1000research.129863.1
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author Knudsen-Clark, Amelia M.
Cazarin, Juliana
Altman, Brian J.
author_facet Knudsen-Clark, Amelia M.
Cazarin, Juliana
Altman, Brian J.
author_sort Knudsen-Clark, Amelia M.
collection PubMed
description Advances in cancer research have made clear the critical role of the immune response in clearing tumors. This breakthrough in scientific understanding was heralded by the success of immune checkpoint blockade (ICB) therapies such as anti-programmed cell death protein 1 (PD-1)/ programmed death-ligand 1 (PD-L1) and anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), as well as the success of chimeric antigen receptor (CAR) T cells in treating liquid tumors. Thus, much effort has been made to further understand the role of the immune response in tumor progression, and how we may target it to treat cancer. Macrophages are a component of the tumor immune microenvironment (TIME) that can promote tumor growth both indirectly, by suppressing T cell responses necessary for tumor killing, as well as directly, through deposition of extracellular matrix and promotion of angiogenesis. Thus, understanding regulation of macrophages within the tumor microenvironment (TME) is key to targeting them for immunotherapy. However, circadian rhythms (24-hour cycles) are a fundamental aspect of macrophage biology that have yet to be investigated for their role in macrophage-mediated suppression of the anti-tumor immune response Circadian rhythms regulate macrophage-mediated immune responses through time-of-day-dependent regulation of macrophage function. A better understanding of the circadian biology of macrophages in the context of the TME may allow us to exploit synergy between existing and upcoming treatments and circadian regulation of immunity.
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spelling pubmed-103526292023-07-19 Do macrophages follow the beat of circadian rhythm in TIME (Tumor Immune Microenvironment)? Knudsen-Clark, Amelia M. Cazarin, Juliana Altman, Brian J. F1000Res Review Advances in cancer research have made clear the critical role of the immune response in clearing tumors. This breakthrough in scientific understanding was heralded by the success of immune checkpoint blockade (ICB) therapies such as anti-programmed cell death protein 1 (PD-1)/ programmed death-ligand 1 (PD-L1) and anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), as well as the success of chimeric antigen receptor (CAR) T cells in treating liquid tumors. Thus, much effort has been made to further understand the role of the immune response in tumor progression, and how we may target it to treat cancer. Macrophages are a component of the tumor immune microenvironment (TIME) that can promote tumor growth both indirectly, by suppressing T cell responses necessary for tumor killing, as well as directly, through deposition of extracellular matrix and promotion of angiogenesis. Thus, understanding regulation of macrophages within the tumor microenvironment (TME) is key to targeting them for immunotherapy. However, circadian rhythms (24-hour cycles) are a fundamental aspect of macrophage biology that have yet to be investigated for their role in macrophage-mediated suppression of the anti-tumor immune response Circadian rhythms regulate macrophage-mediated immune responses through time-of-day-dependent regulation of macrophage function. A better understanding of the circadian biology of macrophages in the context of the TME may allow us to exploit synergy between existing and upcoming treatments and circadian regulation of immunity. F1000 Research Limited 2023-01-27 /pmc/articles/PMC10352629/ /pubmed/37469718 http://dx.doi.org/10.12688/f1000research.129863.1 Text en Copyright: © 2023 Knudsen-Clark AM et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Knudsen-Clark, Amelia M.
Cazarin, Juliana
Altman, Brian J.
Do macrophages follow the beat of circadian rhythm in TIME (Tumor Immune Microenvironment)?
title Do macrophages follow the beat of circadian rhythm in TIME (Tumor Immune Microenvironment)?
title_full Do macrophages follow the beat of circadian rhythm in TIME (Tumor Immune Microenvironment)?
title_fullStr Do macrophages follow the beat of circadian rhythm in TIME (Tumor Immune Microenvironment)?
title_full_unstemmed Do macrophages follow the beat of circadian rhythm in TIME (Tumor Immune Microenvironment)?
title_short Do macrophages follow the beat of circadian rhythm in TIME (Tumor Immune Microenvironment)?
title_sort do macrophages follow the beat of circadian rhythm in time (tumor immune microenvironment)?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352629/
https://www.ncbi.nlm.nih.gov/pubmed/37469718
http://dx.doi.org/10.12688/f1000research.129863.1
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