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Sarcopenia as a Predictive Factor for Recurrence of Hepatocellular Carcinoma Following Radiofrequency Ablation

BACKGROUND: Sarcopenia is a skeletal muscle mass deficiency and a potential prognostic factor for the recurrence of hepatocellular carcinoma (HCC). OBJECTIVE: To determine whether sarcopenia correlates with the recurrence rate of HCC after curative radiofrequency ablation (RFA) in early and very ear...

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Autores principales: Jaruvongvanich, Varin, Thamtorawat, Somrach, Saiviroonporn, Pairash, Pisanuwongse, Arin, Siriwanarangsun, Palanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352721/
https://www.ncbi.nlm.nih.gov/pubmed/37116135
http://dx.doi.org/10.31557/APJCP.2023.24.4.1143
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author Jaruvongvanich, Varin
Thamtorawat, Somrach
Saiviroonporn, Pairash
Pisanuwongse, Arin
Siriwanarangsun, Palanan
author_facet Jaruvongvanich, Varin
Thamtorawat, Somrach
Saiviroonporn, Pairash
Pisanuwongse, Arin
Siriwanarangsun, Palanan
author_sort Jaruvongvanich, Varin
collection PubMed
description BACKGROUND: Sarcopenia is a skeletal muscle mass deficiency and a potential prognostic factor for the recurrence of hepatocellular carcinoma (HCC). OBJECTIVE: To determine whether sarcopenia correlates with the recurrence rate of HCC after curative radiofrequency ablation (RFA) in early and very early HCC. METHODS: We retrospectively reviewed 669 HCC patients who underwent their first curative RFA at Siriraj hospital from 2011 to 2020. Fifty-six patients who were diagnosed with HCC by triple-phase CT scan and had complete response on follow-up CT were included. All patients underwent skeletal muscle index (SMI) assessment at level L3 vertebra and sarcopenia was defined by the cut-off values of 52.4 cm(2)/m(2) for men and 38.5 cm(2)/m(2) for women. We compared patients with and without sarcopenia. Time to recurrence was evaluated by the Kaplan-Meier method. Univariate and multivariate Cox regression analysis was performed. RESULTS: Sarcopenia was present in 37 of 56 patients (66.1%). There was no significant difference between groups except body mass index (BMI) (P<0.001) and serum alanine aminotransferase (ALT) (P=0.035). There was a promising result indicating the difference of time to recurrence between each group (P=0.046) and potential association of sarcopenia with HCC recurrence (HR=2.06; P=0.052). The Child-Pugh score and tumor number were independent risk factors for HCC recurrence (HR=2.04; P=0.005 and HR=2.68; P=0.017, respectively). CONCLUSION: Sarcopenia is a potential prognostic factor for recurrence of HCC in Thai patients who underwent RFA. A larger study is required to properly confirm this association.
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spelling pubmed-103527212023-07-19 Sarcopenia as a Predictive Factor for Recurrence of Hepatocellular Carcinoma Following Radiofrequency Ablation Jaruvongvanich, Varin Thamtorawat, Somrach Saiviroonporn, Pairash Pisanuwongse, Arin Siriwanarangsun, Palanan Asian Pac J Cancer Prev Research Article BACKGROUND: Sarcopenia is a skeletal muscle mass deficiency and a potential prognostic factor for the recurrence of hepatocellular carcinoma (HCC). OBJECTIVE: To determine whether sarcopenia correlates with the recurrence rate of HCC after curative radiofrequency ablation (RFA) in early and very early HCC. METHODS: We retrospectively reviewed 669 HCC patients who underwent their first curative RFA at Siriraj hospital from 2011 to 2020. Fifty-six patients who were diagnosed with HCC by triple-phase CT scan and had complete response on follow-up CT were included. All patients underwent skeletal muscle index (SMI) assessment at level L3 vertebra and sarcopenia was defined by the cut-off values of 52.4 cm(2)/m(2) for men and 38.5 cm(2)/m(2) for women. We compared patients with and without sarcopenia. Time to recurrence was evaluated by the Kaplan-Meier method. Univariate and multivariate Cox regression analysis was performed. RESULTS: Sarcopenia was present in 37 of 56 patients (66.1%). There was no significant difference between groups except body mass index (BMI) (P<0.001) and serum alanine aminotransferase (ALT) (P=0.035). There was a promising result indicating the difference of time to recurrence between each group (P=0.046) and potential association of sarcopenia with HCC recurrence (HR=2.06; P=0.052). The Child-Pugh score and tumor number were independent risk factors for HCC recurrence (HR=2.04; P=0.005 and HR=2.68; P=0.017, respectively). CONCLUSION: Sarcopenia is a potential prognostic factor for recurrence of HCC in Thai patients who underwent RFA. A larger study is required to properly confirm this association. West Asia Organization for Cancer Prevention 2023 /pmc/articles/PMC10352721/ /pubmed/37116135 http://dx.doi.org/10.31557/APJCP.2023.24.4.1143 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Research Article
Jaruvongvanich, Varin
Thamtorawat, Somrach
Saiviroonporn, Pairash
Pisanuwongse, Arin
Siriwanarangsun, Palanan
Sarcopenia as a Predictive Factor for Recurrence of Hepatocellular Carcinoma Following Radiofrequency Ablation
title Sarcopenia as a Predictive Factor for Recurrence of Hepatocellular Carcinoma Following Radiofrequency Ablation
title_full Sarcopenia as a Predictive Factor for Recurrence of Hepatocellular Carcinoma Following Radiofrequency Ablation
title_fullStr Sarcopenia as a Predictive Factor for Recurrence of Hepatocellular Carcinoma Following Radiofrequency Ablation
title_full_unstemmed Sarcopenia as a Predictive Factor for Recurrence of Hepatocellular Carcinoma Following Radiofrequency Ablation
title_short Sarcopenia as a Predictive Factor for Recurrence of Hepatocellular Carcinoma Following Radiofrequency Ablation
title_sort sarcopenia as a predictive factor for recurrence of hepatocellular carcinoma following radiofrequency ablation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352721/
https://www.ncbi.nlm.nih.gov/pubmed/37116135
http://dx.doi.org/10.31557/APJCP.2023.24.4.1143
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