Neurotrophin signalling in the human nervous system

This review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis on their relevance to the function and dysfunction in the human nervous system. It also deals with measurements of BDNF levels and highlights recent findings from our laboratory on TrkB and TrkC signalling in...

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Autores principales: Ateaque, Sarah, Merkouris, Spyros, Barde, Yves-Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352796/
https://www.ncbi.nlm.nih.gov/pubmed/37470055
http://dx.doi.org/10.3389/fnmol.2023.1225373
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author Ateaque, Sarah
Merkouris, Spyros
Barde, Yves-Alain
author_facet Ateaque, Sarah
Merkouris, Spyros
Barde, Yves-Alain
author_sort Ateaque, Sarah
collection PubMed
description This review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis on their relevance to the function and dysfunction in the human nervous system. It also deals with measurements of BDNF levels and highlights recent findings from our laboratory on TrkB and TrkC signalling in human neurons. These include ligand selectivity and Trk activation by neurotrophins and non-neurotrophin ligands. The ligand-induced down-regulation and re-activation of Trk receptors is also discussed.
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spelling pubmed-103527962023-07-19 Neurotrophin signalling in the human nervous system Ateaque, Sarah Merkouris, Spyros Barde, Yves-Alain Front Mol Neurosci Molecular Neuroscience This review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis on their relevance to the function and dysfunction in the human nervous system. It also deals with measurements of BDNF levels and highlights recent findings from our laboratory on TrkB and TrkC signalling in human neurons. These include ligand selectivity and Trk activation by neurotrophins and non-neurotrophin ligands. The ligand-induced down-regulation and re-activation of Trk receptors is also discussed. Frontiers Media S.A. 2023-07-04 /pmc/articles/PMC10352796/ /pubmed/37470055 http://dx.doi.org/10.3389/fnmol.2023.1225373 Text en Copyright © 2023 Ateaque, Merkouris and Barde. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Ateaque, Sarah
Merkouris, Spyros
Barde, Yves-Alain
Neurotrophin signalling in the human nervous system
title Neurotrophin signalling in the human nervous system
title_full Neurotrophin signalling in the human nervous system
title_fullStr Neurotrophin signalling in the human nervous system
title_full_unstemmed Neurotrophin signalling in the human nervous system
title_short Neurotrophin signalling in the human nervous system
title_sort neurotrophin signalling in the human nervous system
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352796/
https://www.ncbi.nlm.nih.gov/pubmed/37470055
http://dx.doi.org/10.3389/fnmol.2023.1225373
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