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Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms
AIMS: In this study, we aimed to investigate the effect of neuropsychiatric symptoms (NPS) on the rate of cognitive decline for both global cognition and specific cognitive domains in a cohort of patients from the Parkinson's Progression Markers Initiative (PPMI). METHOD: Prospectively longitud...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352866/ https://www.ncbi.nlm.nih.gov/pubmed/36924300 http://dx.doi.org/10.1111/cns.14173 |
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author | Meng, Detao Jin, Zhaohui Wang, Yixuan Fang, Boyan |
author_facet | Meng, Detao Jin, Zhaohui Wang, Yixuan Fang, Boyan |
author_sort | Meng, Detao |
collection | PubMed |
description | AIMS: In this study, we aimed to investigate the effect of neuropsychiatric symptoms (NPS) on the rate of cognitive decline for both global cognition and specific cognitive domains in a cohort of patients from the Parkinson's Progression Markers Initiative (PPMI). METHOD: Prospectively longitudinal data were obtained from the PPMI cohort. NPS, including depression, anxiety, apathy, psychosis, impulse control disorders (ICDs), and cognition ability, were evaluated by a series of questionnaires. Linear mixed‐effects models were used to investigate the relationship between NPS and the rate of cognitive decline. Generalized estimating equations (GEEs) were used to investigate the relationship between NPS and the occurrence of mild cognitive impairment (MCI). RESULTS: In total, 423 patients with Parkinson's disease (PD) were recruited at baseline and 395, 378, 366, 346, and 315 participants were followed up at 1, 2, 3, 4, and 5 years, respectively. Depression, anxiety, apathy, and psychosis were associated with global cognitive decline. Except for those with ICDs, patients with psychosis, depression, anxiety, and apathy were more likely to meet the criteria for MCI. Patients with depression and anxiety showed a progressive decline in four major cognitive domains. Apathy and ICDs were separately associated with a progressive decline in processing speed‐attention and memory, respectively. CONCLUSIONS: Neuropsychiatric symptoms, including psychosis, depression, anxiety, and apathy, could be used to predict future cognitive decline in patients with PD. |
format | Online Article Text |
id | pubmed-10352866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103528662023-07-19 Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms Meng, Detao Jin, Zhaohui Wang, Yixuan Fang, Boyan CNS Neurosci Ther Original Articles AIMS: In this study, we aimed to investigate the effect of neuropsychiatric symptoms (NPS) on the rate of cognitive decline for both global cognition and specific cognitive domains in a cohort of patients from the Parkinson's Progression Markers Initiative (PPMI). METHOD: Prospectively longitudinal data were obtained from the PPMI cohort. NPS, including depression, anxiety, apathy, psychosis, impulse control disorders (ICDs), and cognition ability, were evaluated by a series of questionnaires. Linear mixed‐effects models were used to investigate the relationship between NPS and the rate of cognitive decline. Generalized estimating equations (GEEs) were used to investigate the relationship between NPS and the occurrence of mild cognitive impairment (MCI). RESULTS: In total, 423 patients with Parkinson's disease (PD) were recruited at baseline and 395, 378, 366, 346, and 315 participants were followed up at 1, 2, 3, 4, and 5 years, respectively. Depression, anxiety, apathy, and psychosis were associated with global cognitive decline. Except for those with ICDs, patients with psychosis, depression, anxiety, and apathy were more likely to meet the criteria for MCI. Patients with depression and anxiety showed a progressive decline in four major cognitive domains. Apathy and ICDs were separately associated with a progressive decline in processing speed‐attention and memory, respectively. CONCLUSIONS: Neuropsychiatric symptoms, including psychosis, depression, anxiety, and apathy, could be used to predict future cognitive decline in patients with PD. John Wiley and Sons Inc. 2023-03-16 /pmc/articles/PMC10352866/ /pubmed/36924300 http://dx.doi.org/10.1111/cns.14173 Text en © 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Meng, Detao Jin, Zhaohui Wang, Yixuan Fang, Boyan Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms |
title | Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms |
title_full | Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms |
title_fullStr | Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms |
title_full_unstemmed | Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms |
title_short | Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms |
title_sort | longitudinal cognitive changes in patients with early parkinson's disease and neuropsychiatric symptoms |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352866/ https://www.ncbi.nlm.nih.gov/pubmed/36924300 http://dx.doi.org/10.1111/cns.14173 |
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