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Functional recovery continues beyond 3 months post‐basilar artery thrombectomy: A retrospective cohort study

INTRODUCTION: Untreated basilar artery occlusion (BAO) carries 70% mortality. Guidelines recommend thrombectomy with or without thrombolysis. AIM: We compared Modified Rankin Scores (mRS) at 3 and 12 months post thrombectomy to determine benefit of long‐term follow up. METHODS: Retrospective, single...

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Autores principales: Gunasekera, Lakshini, Mitchell, Peter, Dowling, Richard J., Bush, Steven, Yan, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352879/
https://www.ncbi.nlm.nih.gov/pubmed/36942501
http://dx.doi.org/10.1111/cns.14182
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author Gunasekera, Lakshini
Mitchell, Peter
Dowling, Richard J.
Bush, Steven
Yan, Bernard
author_facet Gunasekera, Lakshini
Mitchell, Peter
Dowling, Richard J.
Bush, Steven
Yan, Bernard
author_sort Gunasekera, Lakshini
collection PubMed
description INTRODUCTION: Untreated basilar artery occlusion (BAO) carries 70% mortality. Guidelines recommend thrombectomy with or without thrombolysis. AIM: We compared Modified Rankin Scores (mRS) at 3 and 12 months post thrombectomy to determine benefit of long‐term follow up. METHODS: Retrospective, single centre analysis of BAO thrombectomies between 2015 and 2019. Inclusion criteria were symptomatic BAO on CT angiography, absent early ischemic changes, premorbid independence and intervention within 24 h. All received stroke ward care. Results were analysed with simple statistics and binary logistic regression as appropriate. RESULTS: Of 82 patients: most were male (61%, 50/82) with median age 68 years (IQR 17 years) and median NIHSS 14 (IQR 15). Median door‐to‐puncture time was 42 min (IQR 72 min). Total deaths were 34.1% (28/82) at 3 months, and 37.8% (31/82) at 12 months. Of 51 patients alive at 12 months: 41% (21/51) had improved mRS, 16% (8/51) had worse mRS and 43% (22/51) had unchanged mRS, compared to 3 months. Improvements to mRS were: one point in 57.1% (14/21), two points in 28.9% (6/21) and three points in 4.8% (1/21). Nursing home admission was avoided in 11.8% (6/51) who improved from mRS4. Increased age was associated with decreased likelihood of reaching the primary outcome OR 0.87, 95% CI 0.76–0.99 (p value = 0.03). CONCLUSION: Over a quarter of patients improved beyond 3 months. Future studies should adopt long‐term follow up as primary outcome.
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spelling pubmed-103528792023-07-19 Functional recovery continues beyond 3 months post‐basilar artery thrombectomy: A retrospective cohort study Gunasekera, Lakshini Mitchell, Peter Dowling, Richard J. Bush, Steven Yan, Bernard CNS Neurosci Ther Original Articles INTRODUCTION: Untreated basilar artery occlusion (BAO) carries 70% mortality. Guidelines recommend thrombectomy with or without thrombolysis. AIM: We compared Modified Rankin Scores (mRS) at 3 and 12 months post thrombectomy to determine benefit of long‐term follow up. METHODS: Retrospective, single centre analysis of BAO thrombectomies between 2015 and 2019. Inclusion criteria were symptomatic BAO on CT angiography, absent early ischemic changes, premorbid independence and intervention within 24 h. All received stroke ward care. Results were analysed with simple statistics and binary logistic regression as appropriate. RESULTS: Of 82 patients: most were male (61%, 50/82) with median age 68 years (IQR 17 years) and median NIHSS 14 (IQR 15). Median door‐to‐puncture time was 42 min (IQR 72 min). Total deaths were 34.1% (28/82) at 3 months, and 37.8% (31/82) at 12 months. Of 51 patients alive at 12 months: 41% (21/51) had improved mRS, 16% (8/51) had worse mRS and 43% (22/51) had unchanged mRS, compared to 3 months. Improvements to mRS were: one point in 57.1% (14/21), two points in 28.9% (6/21) and three points in 4.8% (1/21). Nursing home admission was avoided in 11.8% (6/51) who improved from mRS4. Increased age was associated with decreased likelihood of reaching the primary outcome OR 0.87, 95% CI 0.76–0.99 (p value = 0.03). CONCLUSION: Over a quarter of patients improved beyond 3 months. Future studies should adopt long‐term follow up as primary outcome. John Wiley and Sons Inc. 2023-03-21 /pmc/articles/PMC10352879/ /pubmed/36942501 http://dx.doi.org/10.1111/cns.14182 Text en © 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Gunasekera, Lakshini
Mitchell, Peter
Dowling, Richard J.
Bush, Steven
Yan, Bernard
Functional recovery continues beyond 3 months post‐basilar artery thrombectomy: A retrospective cohort study
title Functional recovery continues beyond 3 months post‐basilar artery thrombectomy: A retrospective cohort study
title_full Functional recovery continues beyond 3 months post‐basilar artery thrombectomy: A retrospective cohort study
title_fullStr Functional recovery continues beyond 3 months post‐basilar artery thrombectomy: A retrospective cohort study
title_full_unstemmed Functional recovery continues beyond 3 months post‐basilar artery thrombectomy: A retrospective cohort study
title_short Functional recovery continues beyond 3 months post‐basilar artery thrombectomy: A retrospective cohort study
title_sort functional recovery continues beyond 3 months post‐basilar artery thrombectomy: a retrospective cohort study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352879/
https://www.ncbi.nlm.nih.gov/pubmed/36942501
http://dx.doi.org/10.1111/cns.14182
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