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Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta‐analysis

BACKGROUND: Rapid diagnosis of acute ischemic stroke (AIS) patients is still challenging, and reliable biomarkers are needed. Noncoding RNAs are important for many physiological activities, among which circular RNAs (circRNAs) have been proven to be more tissue‐specific and conservative. Many recent...

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Autores principales: Zhang, Xiao, Wan, Mengyao, Min, Xiaoli, Chu, Guanglei, Luo, Yumin, Han, Ziping, Li, Wei, Xu, Ran, Luo, Jichang, Li, Wenjing, Yang, Yutong, Ma, Yan, Jiao, Liqun, Wang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352895/
https://www.ncbi.nlm.nih.gov/pubmed/37186176
http://dx.doi.org/10.1111/cns.14220
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author Zhang, Xiao
Wan, Mengyao
Min, Xiaoli
Chu, Guanglei
Luo, Yumin
Han, Ziping
Li, Wei
Xu, Ran
Luo, Jichang
Li, Wenjing
Yang, Yutong
Ma, Yan
Jiao, Liqun
Wang, Tao
author_facet Zhang, Xiao
Wan, Mengyao
Min, Xiaoli
Chu, Guanglei
Luo, Yumin
Han, Ziping
Li, Wei
Xu, Ran
Luo, Jichang
Li, Wenjing
Yang, Yutong
Ma, Yan
Jiao, Liqun
Wang, Tao
author_sort Zhang, Xiao
collection PubMed
description BACKGROUND: Rapid diagnosis of acute ischemic stroke (AIS) patients is still challenging, and reliable biomarkers are needed. Noncoding RNAs are important for many physiological activities, among which circular RNAs (circRNAs) have been proven to be more tissue‐specific and conservative. Many recent studies found the potential of circRNAs as biomarkers for many diseases, including cardiovascular diseases, cancers, and ischemic stroke. This systemic review and meta‐analysis aimed to identify circRNAs as potential biomarkers for AIS. METHODS: This study has been prospectively registered in PROSPERO (Registration No. 11 CRD42021288033). Published literature comparing circRNA expression profiles between AIS and non‐AIS in human and animal models were retrieved from the articles published by January 2023 in major databases. We descriptively summarized the included studies, conducted meta‐analysis under a random effects model, and did bioinformatics analysis including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. RESULTS: Totally 23 studies were included, reporting 18 distinctive upregulated and 20 distinctive downregulated circRNAs. Diagnostic meta‐analysis indicated discriminative ability of the circRNAs. Furthermore, circRNA HECTD1, circRNA DLGAP4, circRNA CDC14A, circRNA SCMH1, and circRNA TLK1 were reported with the same regulation trend in more than one study (animal studies included). GO and KEGG enrichment analyses indicated that the target genes of these five circRNAs were enriched in regulating cell proliferation, apoptosis, and oxidative stress. CONCLUSIONS: This study demonstrates that circRNAs (circRNA HECTD1, circRNA DLGAP4, circRNA CDC14A, circRNA SCMH1, and circRNA TLK1) generally are promising as potential biomarkers for AIS. However, due to the limited number of studies, diagnostic value of individual circRNA could not be validated. More in vitro and in vivo functional studies are needed.
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spelling pubmed-103528952023-07-19 Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta‐analysis Zhang, Xiao Wan, Mengyao Min, Xiaoli Chu, Guanglei Luo, Yumin Han, Ziping Li, Wei Xu, Ran Luo, Jichang Li, Wenjing Yang, Yutong Ma, Yan Jiao, Liqun Wang, Tao CNS Neurosci Ther Meta‐analysis BACKGROUND: Rapid diagnosis of acute ischemic stroke (AIS) patients is still challenging, and reliable biomarkers are needed. Noncoding RNAs are important for many physiological activities, among which circular RNAs (circRNAs) have been proven to be more tissue‐specific and conservative. Many recent studies found the potential of circRNAs as biomarkers for many diseases, including cardiovascular diseases, cancers, and ischemic stroke. This systemic review and meta‐analysis aimed to identify circRNAs as potential biomarkers for AIS. METHODS: This study has been prospectively registered in PROSPERO (Registration No. 11 CRD42021288033). Published literature comparing circRNA expression profiles between AIS and non‐AIS in human and animal models were retrieved from the articles published by January 2023 in major databases. We descriptively summarized the included studies, conducted meta‐analysis under a random effects model, and did bioinformatics analysis including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. RESULTS: Totally 23 studies were included, reporting 18 distinctive upregulated and 20 distinctive downregulated circRNAs. Diagnostic meta‐analysis indicated discriminative ability of the circRNAs. Furthermore, circRNA HECTD1, circRNA DLGAP4, circRNA CDC14A, circRNA SCMH1, and circRNA TLK1 were reported with the same regulation trend in more than one study (animal studies included). GO and KEGG enrichment analyses indicated that the target genes of these five circRNAs were enriched in regulating cell proliferation, apoptosis, and oxidative stress. CONCLUSIONS: This study demonstrates that circRNAs (circRNA HECTD1, circRNA DLGAP4, circRNA CDC14A, circRNA SCMH1, and circRNA TLK1) generally are promising as potential biomarkers for AIS. However, due to the limited number of studies, diagnostic value of individual circRNA could not be validated. More in vitro and in vivo functional studies are needed. John Wiley and Sons Inc. 2023-04-26 /pmc/articles/PMC10352895/ /pubmed/37186176 http://dx.doi.org/10.1111/cns.14220 Text en © 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Meta‐analysis
Zhang, Xiao
Wan, Mengyao
Min, Xiaoli
Chu, Guanglei
Luo, Yumin
Han, Ziping
Li, Wei
Xu, Ran
Luo, Jichang
Li, Wenjing
Yang, Yutong
Ma, Yan
Jiao, Liqun
Wang, Tao
Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta‐analysis
title Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta‐analysis
title_full Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta‐analysis
title_fullStr Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta‐analysis
title_full_unstemmed Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta‐analysis
title_short Circular RNA as biomarkers for acute ischemic stroke: A systematic review and meta‐analysis
title_sort circular rna as biomarkers for acute ischemic stroke: a systematic review and meta‐analysis
topic Meta‐analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352895/
https://www.ncbi.nlm.nih.gov/pubmed/37186176
http://dx.doi.org/10.1111/cns.14220
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