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Overview of research progress and application of experimental models of colorectal cancer

Colorectal cancer (CRC) is the third most common malignancy in terms of global tumor incidence, and the rates of morbidity and mortality due to CRC are rising. Experimental models of CRC play a vital role in CRC research. Clinical studies aimed at investigating the evolution and mechanism underlying...

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Autores principales: Liu, Li, Yan, Qiuying, Chen, Zihan, Wei, Xiaoman, Li, Lin, Tang, Dongxin, Tan, Jiani, Xu, Changliang, Yu, Chengtao, Lai, Yueyang, Fan, Minmin, Tao, Lihuiping, Shen, Weixing, Li, Liu, Wu, Mianhua, Cheng, Haibo, Sun, Dongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352992/
https://www.ncbi.nlm.nih.gov/pubmed/37469864
http://dx.doi.org/10.3389/fphar.2023.1193213
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author Liu, Li
Yan, Qiuying
Chen, Zihan
Wei, Xiaoman
Li, Lin
Tang, Dongxin
Tan, Jiani
Xu, Changliang
Yu, Chengtao
Lai, Yueyang
Fan, Minmin
Tao, Lihuiping
Shen, Weixing
Li, Liu
Wu, Mianhua
Cheng, Haibo
Sun, Dongdong
author_facet Liu, Li
Yan, Qiuying
Chen, Zihan
Wei, Xiaoman
Li, Lin
Tang, Dongxin
Tan, Jiani
Xu, Changliang
Yu, Chengtao
Lai, Yueyang
Fan, Minmin
Tao, Lihuiping
Shen, Weixing
Li, Liu
Wu, Mianhua
Cheng, Haibo
Sun, Dongdong
author_sort Liu, Li
collection PubMed
description Colorectal cancer (CRC) is the third most common malignancy in terms of global tumor incidence, and the rates of morbidity and mortality due to CRC are rising. Experimental models of CRC play a vital role in CRC research. Clinical studies aimed at investigating the evolution and mechanism underlying the formation of CRC are based on cellular and animal models with broad applications. The present review classifies the different experimental models used in CRC research, and describes the characteristics and limitations of these models by comparing the research models with the clinical symptoms. The review also discusses the future prospects of developing new experimental models of CRC.
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spelling pubmed-103529922023-07-19 Overview of research progress and application of experimental models of colorectal cancer Liu, Li Yan, Qiuying Chen, Zihan Wei, Xiaoman Li, Lin Tang, Dongxin Tan, Jiani Xu, Changliang Yu, Chengtao Lai, Yueyang Fan, Minmin Tao, Lihuiping Shen, Weixing Li, Liu Wu, Mianhua Cheng, Haibo Sun, Dongdong Front Pharmacol Pharmacology Colorectal cancer (CRC) is the third most common malignancy in terms of global tumor incidence, and the rates of morbidity and mortality due to CRC are rising. Experimental models of CRC play a vital role in CRC research. Clinical studies aimed at investigating the evolution and mechanism underlying the formation of CRC are based on cellular and animal models with broad applications. The present review classifies the different experimental models used in CRC research, and describes the characteristics and limitations of these models by comparing the research models with the clinical symptoms. The review also discusses the future prospects of developing new experimental models of CRC. Frontiers Media S.A. 2023-07-04 /pmc/articles/PMC10352992/ /pubmed/37469864 http://dx.doi.org/10.3389/fphar.2023.1193213 Text en Copyright © 2023 Liu, Yan, Chen, Wei, Li, Tang, Tan, Xu, Yu, Lai, Fan, Tao, Shen, Li, Wu, Cheng and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liu, Li
Yan, Qiuying
Chen, Zihan
Wei, Xiaoman
Li, Lin
Tang, Dongxin
Tan, Jiani
Xu, Changliang
Yu, Chengtao
Lai, Yueyang
Fan, Minmin
Tao, Lihuiping
Shen, Weixing
Li, Liu
Wu, Mianhua
Cheng, Haibo
Sun, Dongdong
Overview of research progress and application of experimental models of colorectal cancer
title Overview of research progress and application of experimental models of colorectal cancer
title_full Overview of research progress and application of experimental models of colorectal cancer
title_fullStr Overview of research progress and application of experimental models of colorectal cancer
title_full_unstemmed Overview of research progress and application of experimental models of colorectal cancer
title_short Overview of research progress and application of experimental models of colorectal cancer
title_sort overview of research progress and application of experimental models of colorectal cancer
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10352992/
https://www.ncbi.nlm.nih.gov/pubmed/37469864
http://dx.doi.org/10.3389/fphar.2023.1193213
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