Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents

An optimization strategy was adopted for designing and synthesizing new series of 2-oxindole conjugates. Selected compounds were evaluated for their antiproliferative effect in vitro against NCI-60 cell lines panel, inhibitory effect on carbonic anhydrase (CA) isoforms (hCAI, II, IX and XII), and pr...

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Detalles Bibliográficos
Autores principales: Ismail, Rania S. M., El Kerdawy, Ahmed M., Soliman, Dalia H., Georgey, Hanan H., Abdel Gawad, Nagwa M., Angeli, Andrea, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353187/
https://www.ncbi.nlm.nih.gov/pubmed/37461110
http://dx.doi.org/10.1186/s13065-023-00994-3

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