Hybridization of the effective pharmacophores for treatment of epilepsy: design, synthesis, in vivo anticonvulsant activity, and in silico studies of phenoxyphenyl-1,3,4-oxadiazole-thio-N-phenylacetamid hybrids

BACKGROUND: Epilepsy is a common neurological disorder. The available drugs for this disease only control convulsions in nearly 70% of patients, while bearing many side effects. In this study, a new series of phenoxyphenyl-1,3,4-oxadiazole-thio-N-phenylacetamid hybrids 8a-m was designed, synthesized...

Descripción completa

Detalles Bibliográficos
Autores principales: Fakhrioliaei, Azadeh, Abedinifar, Fahimeh, Salehi Darjani, Pedram, Mohammadi-Khanaposhtani, Maryam, Larijani, Bagher, Ahangar, Nematollah, Mahdavi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353189/
https://www.ncbi.nlm.nih.gov/pubmed/37461080
http://dx.doi.org/10.1186/s13065-023-01000-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353189/
https://www.ncbi.nlm.nih.gov/pubmed/37461080
http://dx.doi.org/10.1186/s13065-023-01000-6

Ejemplares similares