Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies

Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are promising candidates for immune-related disease treatment. However, the effect of MSC applicat...

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Autores principales: Yang, Xue, Wang, Ying, Rovella, Valentina, Candi, Eleonora, Jia, Wei, Bernassola, Francesca, Bove, Pierluigi, Piacentini, Mauro, Scimeca, Manuel, Sica, Giuseppe, Tisone, Giuseppe, Mauriello, Alessandro, Wei, Lixin, Melino, Gerry, Shi, Yufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353240/
https://www.ncbi.nlm.nih.gov/pubmed/37464416
http://dx.doi.org/10.1186/s13062-023-00394-6
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author Yang, Xue
Wang, Ying
Rovella, Valentina
Candi, Eleonora
Jia, Wei
Bernassola, Francesca
Bove, Pierluigi
Piacentini, Mauro
Scimeca, Manuel
Sica, Giuseppe
Tisone, Giuseppe
Mauriello, Alessandro
Wei, Lixin
Melino, Gerry
Shi, Yufang
author_facet Yang, Xue
Wang, Ying
Rovella, Valentina
Candi, Eleonora
Jia, Wei
Bernassola, Francesca
Bove, Pierluigi
Piacentini, Mauro
Scimeca, Manuel
Sica, Giuseppe
Tisone, Giuseppe
Mauriello, Alessandro
Wei, Lixin
Melino, Gerry
Shi, Yufang
author_sort Yang, Xue
collection PubMed
description Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are promising candidates for immune-related disease treatment. However, the effect of MSC application is not satisfactory for some patients, especially in elderly individuals. With ageing, MSCs undergo many changes, including altered cell population reduction and differentiation ability, reduced migratory and homing capacity and, most important, defective immunosuppression. It is necessary to explore the relationship between the “inflammaging” and aged MSCs to prevent age-related diseases and increase the therapeutic effects of MSCs. In this review, we discuss changes in naturally ageing MSCs mainly from an inflammation perspective and propose some ideas for rejuvenating aged MSCs in future treatments.
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spelling pubmed-103532402023-07-19 Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies Yang, Xue Wang, Ying Rovella, Valentina Candi, Eleonora Jia, Wei Bernassola, Francesca Bove, Pierluigi Piacentini, Mauro Scimeca, Manuel Sica, Giuseppe Tisone, Giuseppe Mauriello, Alessandro Wei, Lixin Melino, Gerry Shi, Yufang Biol Direct Review Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are promising candidates for immune-related disease treatment. However, the effect of MSC application is not satisfactory for some patients, especially in elderly individuals. With ageing, MSCs undergo many changes, including altered cell population reduction and differentiation ability, reduced migratory and homing capacity and, most important, defective immunosuppression. It is necessary to explore the relationship between the “inflammaging” and aged MSCs to prevent age-related diseases and increase the therapeutic effects of MSCs. In this review, we discuss changes in naturally ageing MSCs mainly from an inflammation perspective and propose some ideas for rejuvenating aged MSCs in future treatments. BioMed Central 2023-07-18 /pmc/articles/PMC10353240/ /pubmed/37464416 http://dx.doi.org/10.1186/s13062-023-00394-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yang, Xue
Wang, Ying
Rovella, Valentina
Candi, Eleonora
Jia, Wei
Bernassola, Francesca
Bove, Pierluigi
Piacentini, Mauro
Scimeca, Manuel
Sica, Giuseppe
Tisone, Giuseppe
Mauriello, Alessandro
Wei, Lixin
Melino, Gerry
Shi, Yufang
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
title Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
title_full Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
title_fullStr Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
title_full_unstemmed Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
title_short Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
title_sort aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353240/
https://www.ncbi.nlm.nih.gov/pubmed/37464416
http://dx.doi.org/10.1186/s13062-023-00394-6
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