Phosphoproteome Profiling of Klebsiella pneumoniae under Zinc-Limited and Zinc-Replete Conditions

The bacterial pathogen Klebsiella pneumoniae causes nosocomial infections with the acquisition of multidrug resistance, impeding treatment options. This study investigated the effect of zinc limitation on the phosphoproteome of K. pneumoniae using quantitative mass spectrometry. New insight is provi...

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Detalles Bibliográficos
Autores principales: Reitzel, Chelsea, Sukumaran, Arjun, Zanetti, Christina, Muselius, Benjamin, Geddes-McAlister, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Omics Data Sets
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353368/
https://www.ncbi.nlm.nih.gov/pubmed/37358435
http://dx.doi.org/10.1128/mra.00258-23
Descripción
Sumario:The bacterial pathogen Klebsiella pneumoniae causes nosocomial infections with the acquisition of multidrug resistance, impeding treatment options. This study investigated the effect of zinc limitation on the phosphoproteome of K. pneumoniae using quantitative mass spectrometry. New insight is provided into cellular signaling methods used by the pathogen to respond to nutrient-limited environments.

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