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The effect of the alpha-specific PI3K inhibitor alpelisib combined with anti-HER2 therapy in HER2+/PIK3CA mutant breast cancer

BACKGROUND: HER2 is amplified or overexpressed in around 20% of breast cancers (BC). HER2-targeted therapies have significantly improved the prognosis of patients with HER2+ BC, however, de novo and acquired resistance to anti-HER2 treatment is common. Activating mutations in the PIK3CA gene are rep...

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Detalles Bibliográficos
Autores principales:	Cataldo, Maria Letizia, De Placido, Pietro, Esposito, Daniela, Formisano, Luigi, Arpino, Grazia, Giuliano, Mario, Bianco, Roberto, De Angelis, Carmine, Veneziani, Bianca Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353540/ https://www.ncbi.nlm.nih.gov/pubmed/37469415 http://dx.doi.org/10.3389/fonc.2023.1108242

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