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1-Year Prospective Study of the Relationship of Serial Exhaled Nitric Oxide Level and Asthma Control
BACKGROUND AND OBJECTIVE: Previous studies found that the fractional nitric oxide concentration in exhaled breath (FeNO) levels in healthy Chinese adults was higher than in White adults. More understanding of serial changes of FeNO levels with asthma control in a real-life clinical setting would be...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353557/ https://www.ncbi.nlm.nih.gov/pubmed/37469451 http://dx.doi.org/10.2147/JAA.S417117 |
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author | Ko, Fanny Wai San Chan, Ka Pang Ng, Joyce Ka Ching Ngai, Jenny C L Yip, Wing Ho Lo, Rachel Lai Ping Chan, Tat On Hui, David Shu Cheong |
author_facet | Ko, Fanny Wai San Chan, Ka Pang Ng, Joyce Ka Ching Ngai, Jenny C L Yip, Wing Ho Lo, Rachel Lai Ping Chan, Tat On Hui, David Shu Cheong |
author_sort | Ko, Fanny Wai San |
collection | PubMed |
description | BACKGROUND AND OBJECTIVE: Previous studies found that the fractional nitric oxide concentration in exhaled breath (FeNO) levels in healthy Chinese adults was higher than in White adults. More understanding of serial changes of FeNO levels with asthma control in a real-life clinical setting would be important to explore the utility of this biomarker in routine asthma management. This study assessed the FeNO levels of Chinese asthma subjects with different levels of asthma control and the serial changes with respect to the changes in asthma control over 1 year. METHODS: A 12-month prospective study (subjects recruited between November 2019 and January 2021) with serial measurement of FeNO levels at baseline, 4, 8 and 12 months. Asthma control was assessed by the Global Initiative for Asthma classification, Asthma Control Test (ACT) and Asthma Control Questionnaire (ACQ). RESULTS: Altogether, 136 subjects (mean age 51.51±15.09 years, 46[33.8%] male) had successful baseline FeNO measurements. At baseline, the FeNO levels did not show a statistically significant difference for controlled, partly controlled and uncontrolled asthma according to GINA classification, ACT and ACQ. FeNO levels decreased with improving asthma control and stayed at similar levels with unchanged or worsening asthma control for all subjects. For subjects with baseline blood eosinophil levels ≥300 cells/µL(n=59), FeNO levels decreased with improving asthma control, stayed similar without change for asthma control and increased with worsening asthma control. Receiver operating characteristic (ROC) analysis with the highest area under curve (AUC) for changes in FeNO levels for improving asthma control was between ≤ −10 to −25 ppb at various time points in the 12-month study. CONCLUSION: Changes in FeNO levels over time were associated with changes in clinical asthma control, particularly in those with higher blood eosinophil count and are likely more useful than a single time point measurement in managing asthma. |
format | Online Article Text |
id | pubmed-10353557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-103535572023-07-19 1-Year Prospective Study of the Relationship of Serial Exhaled Nitric Oxide Level and Asthma Control Ko, Fanny Wai San Chan, Ka Pang Ng, Joyce Ka Ching Ngai, Jenny C L Yip, Wing Ho Lo, Rachel Lai Ping Chan, Tat On Hui, David Shu Cheong J Asthma Allergy Original Research BACKGROUND AND OBJECTIVE: Previous studies found that the fractional nitric oxide concentration in exhaled breath (FeNO) levels in healthy Chinese adults was higher than in White adults. More understanding of serial changes of FeNO levels with asthma control in a real-life clinical setting would be important to explore the utility of this biomarker in routine asthma management. This study assessed the FeNO levels of Chinese asthma subjects with different levels of asthma control and the serial changes with respect to the changes in asthma control over 1 year. METHODS: A 12-month prospective study (subjects recruited between November 2019 and January 2021) with serial measurement of FeNO levels at baseline, 4, 8 and 12 months. Asthma control was assessed by the Global Initiative for Asthma classification, Asthma Control Test (ACT) and Asthma Control Questionnaire (ACQ). RESULTS: Altogether, 136 subjects (mean age 51.51±15.09 years, 46[33.8%] male) had successful baseline FeNO measurements. At baseline, the FeNO levels did not show a statistically significant difference for controlled, partly controlled and uncontrolled asthma according to GINA classification, ACT and ACQ. FeNO levels decreased with improving asthma control and stayed at similar levels with unchanged or worsening asthma control for all subjects. For subjects with baseline blood eosinophil levels ≥300 cells/µL(n=59), FeNO levels decreased with improving asthma control, stayed similar without change for asthma control and increased with worsening asthma control. Receiver operating characteristic (ROC) analysis with the highest area under curve (AUC) for changes in FeNO levels for improving asthma control was between ≤ −10 to −25 ppb at various time points in the 12-month study. CONCLUSION: Changes in FeNO levels over time were associated with changes in clinical asthma control, particularly in those with higher blood eosinophil count and are likely more useful than a single time point measurement in managing asthma. Dove 2023-07-14 /pmc/articles/PMC10353557/ /pubmed/37469451 http://dx.doi.org/10.2147/JAA.S417117 Text en © 2023 Ko et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Ko, Fanny Wai San Chan, Ka Pang Ng, Joyce Ka Ching Ngai, Jenny C L Yip, Wing Ho Lo, Rachel Lai Ping Chan, Tat On Hui, David Shu Cheong 1-Year Prospective Study of the Relationship of Serial Exhaled Nitric Oxide Level and Asthma Control |
title | 1-Year Prospective Study of the Relationship of Serial Exhaled Nitric Oxide Level and Asthma Control |
title_full | 1-Year Prospective Study of the Relationship of Serial Exhaled Nitric Oxide Level and Asthma Control |
title_fullStr | 1-Year Prospective Study of the Relationship of Serial Exhaled Nitric Oxide Level and Asthma Control |
title_full_unstemmed | 1-Year Prospective Study of the Relationship of Serial Exhaled Nitric Oxide Level and Asthma Control |
title_short | 1-Year Prospective Study of the Relationship of Serial Exhaled Nitric Oxide Level and Asthma Control |
title_sort | 1-year prospective study of the relationship of serial exhaled nitric oxide level and asthma control |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353557/ https://www.ncbi.nlm.nih.gov/pubmed/37469451 http://dx.doi.org/10.2147/JAA.S417117 |
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