Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells

Mannose has anticancer activity that inhibits cell proliferation and enhances the efficacy of chemotherapy. How mannose exerts its anticancer activity, however, remains poorly understood. Here, using genetically engineered human cancer cells that permit the precise control of mannose metabolic flux,...

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Detalles Bibliográficos
Autores principales: Harada, Yoichiro, Mizote, Yu, Suzuki, Takehiro, Hirayama, Akiyoshi, Ikeda, Satsuki, Nishida, Mikako, Hiratsuka, Toru, Ueda, Ayaka, Imagawa, Yusuke, Maeda, Kento, Ohkawa, Yuki, Murai, Junko, Freeze, Hudson H, Miyoshi, Eiji, Higashiyama, Shigeki, Udono, Heiichiro, Dohmae, Naoshi, Tahara, Hideaki, Taniguchi, Naoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353863/
https://www.ncbi.nlm.nih.gov/pubmed/37461317
http://dx.doi.org/10.7554/eLife.83870

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