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Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease

cGAMP-specific nucleases (poxins) are a recently described family of proteins dedicated to obstructing cyclic GMP-AMP synthase signaling (cGAS), an important sensor triggered by cytoplasmic viral replication that activates type I interferon (IFN) production. The B2R gene of vaccinia viruses (VACV) c...

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Detalles Bibliográficos
Autores principales:	Riederer, Stephanie, del Canizo, Ana, Navas, Javier, Peter, Marlowe G., Link, Ellen K., Sutter, Gerd, Rojas, Juan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353925/ https://www.ncbi.nlm.nih.gov/pubmed/37016144 http://dx.doi.org/10.1038/s41417-023-00610-5

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