Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia

In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia (R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable remissions, which requires the persistence of CAR-T cells. In this study, we systematically analyzed CD19 CAR-T cells o...

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Detalles Bibliográficos
Autores principales: Anderson, Nathaniel D., Birch, Jack, Accogli, Theo, Criado, Ignacio, Khabirova, Eleonora, Parks, Conor, Wood, Yvette, Young, Matthew D., Porter, Tarryn, Richardson, Rachel, Albon, Sarah J., Popova, Bilyana, Lopes, Andre, Wynn, Robert, Hough, Rachael, Gohil, Satyen H., Pule, Martin, Amrolia, Persis J., Behjati, Sam, Ghorashian, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353931/
https://www.ncbi.nlm.nih.gov/pubmed/37407840
http://dx.doi.org/10.1038/s41591-023-02415-3

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