Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

Older age is one of the strongest risk factors for severe COVID-19. In this study, we determined whether age-associated cellular senescence contributes to the severity of experimental COVID-19. Aged golden hamsters accumulate senescent cells in the lungs, and the senolytic drug ABT-263, a BCL-2 inhi...

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Detalles Bibliográficos
Autores principales: Delval, Lou, Hantute-Ghesquier, Aline, Sencio, Valentin, Flaman, Jean Michel, Robil, Cyril, Angulo, Fabiola Silva, Lipskaia, Larissa, Çobanoğlu, Ozmen, Lacoste, Anne-Sophie, Machelart, Arnaud, Danneels, Adeline, Corbin, Mathieu, Deruyter, Lucie, Heumel, Séverine, Idziorek, Thierry, Séron, Karin, Sauve, Florent, Bongiovanni, Antonino, Prévot, Vincent, Wolowczuk, Isabelle, Belouzard, Sandrine, Saliou, Jean-Michel, Gosset, Philippe, Bernard, David, Rouillé, Yves, Adnot, Serge, Duterque-Coquillaud, Martine, Trottein, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353934/
https://www.ncbi.nlm.nih.gov/pubmed/37414987
http://dx.doi.org/10.1038/s43587-023-00442-w

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