Clonal hematopoiesis is associated with protection from Alzheimer’s disease

Clonal hematopoiesis of indeterminate potential (CHIP) is a premalignant expansion of mutated hematopoietic stem cells. As CHIP-associated mutations are known to alter the development and function of myeloid cells, we hypothesized that CHIP may also be associated with the risk of Alzheimer’s disease...

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Detalles Bibliográficos
Autores principales: Bouzid, Hind, Belk, Julia A., Jan, Max, Qi, Yanyan, Sarnowski, Chloé, Wirth, Sara, Ma, Lisa, Chrostek, Matthew R., Ahmad, Herra, Nachun, Daniel, Yao, Winnie, Beiser, Alexa, Bick, Alexander G., Bis, Joshua C., Fornage, Myriam, Longstreth, William T., Lopez, Oscar L., Natarajan, Pradeep, Psaty, Bruce M., Satizabal, Claudia L., Weinstock, Joshua, Larson, Eric B., Crane, Paul K., Keene, C. Dirk, Seshadri, Sudha, Satpathy, Ansuman T., Montine, Thomas J., Jaiswal, Siddhartha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353941/
https://www.ncbi.nlm.nih.gov/pubmed/37322115
http://dx.doi.org/10.1038/s41591-023-02397-2

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