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An Update on the Diagnosis and Management of Calcium Crystal Disease

PURPOSE OF REVIEW: This article aims to review the challenges to diagnosis and management of calcium crystal deposition diseases and evaluate the literature published over the past 3 years. RECENT FINDINGS: The awaited development of classification criteria is an essential step in the progression of...

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Autores principales: Flood, Rachael, Stack, John, McCarthy, Geraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353954/
https://www.ncbi.nlm.nih.gov/pubmed/37249830
http://dx.doi.org/10.1007/s11926-023-01106-9
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author Flood, Rachael
Stack, John
McCarthy, Geraldine
author_facet Flood, Rachael
Stack, John
McCarthy, Geraldine
author_sort Flood, Rachael
collection PubMed
description PURPOSE OF REVIEW: This article aims to review the challenges to diagnosis and management of calcium crystal deposition diseases and evaluate the literature published over the past 3 years. RECENT FINDINGS: The awaited development of classification criteria is an essential step in the progression of calcium crystal deposition disease clinical research. There have been recent improvements in the accuracy of imaging for the diagnosis of crystal deposition diseases with published definitions of characteristic features. Factors associated with acute flares of disease have been identified and an association with increased cardiovascular risk has been demonstrated. Targeted treatment options for calcium crystal diseases remain elusive. However, there have been advances in understanding the molecular mechanisms of disease revealing potential targets for future drug development. SUMMARY: Calcium-crystal deposition diseases are increasing in incidence and prevalence as populations age and continue to associate with a high burden of disability. Despite this, calcium crystal deposition disease remains under-studied with a paucity of evidence-based treatment guidelines.
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spelling pubmed-103539542023-07-20 An Update on the Diagnosis and Management of Calcium Crystal Disease Flood, Rachael Stack, John McCarthy, Geraldine Curr Rheumatol Rep Article PURPOSE OF REVIEW: This article aims to review the challenges to diagnosis and management of calcium crystal deposition diseases and evaluate the literature published over the past 3 years. RECENT FINDINGS: The awaited development of classification criteria is an essential step in the progression of calcium crystal deposition disease clinical research. There have been recent improvements in the accuracy of imaging for the diagnosis of crystal deposition diseases with published definitions of characteristic features. Factors associated with acute flares of disease have been identified and an association with increased cardiovascular risk has been demonstrated. Targeted treatment options for calcium crystal diseases remain elusive. However, there have been advances in understanding the molecular mechanisms of disease revealing potential targets for future drug development. SUMMARY: Calcium-crystal deposition diseases are increasing in incidence and prevalence as populations age and continue to associate with a high burden of disability. Despite this, calcium crystal deposition disease remains under-studied with a paucity of evidence-based treatment guidelines. Springer US 2023-05-30 2023 /pmc/articles/PMC10353954/ /pubmed/37249830 http://dx.doi.org/10.1007/s11926-023-01106-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Flood, Rachael
Stack, John
McCarthy, Geraldine
An Update on the Diagnosis and Management of Calcium Crystal Disease
title An Update on the Diagnosis and Management of Calcium Crystal Disease
title_full An Update on the Diagnosis and Management of Calcium Crystal Disease
title_fullStr An Update on the Diagnosis and Management of Calcium Crystal Disease
title_full_unstemmed An Update on the Diagnosis and Management of Calcium Crystal Disease
title_short An Update on the Diagnosis and Management of Calcium Crystal Disease
title_sort update on the diagnosis and management of calcium crystal disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10353954/
https://www.ncbi.nlm.nih.gov/pubmed/37249830
http://dx.doi.org/10.1007/s11926-023-01106-9
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