Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter

The TWIK-related spinal cord K(+) channel (TRESK, K(2P)18.1) is a K(2P) channel contributing to the maintenance of membrane potentials in various cells. Recently, physiological TRESK function was identified as a key player in T-cell differentiation rendering the channel a new pharmacological target...

Descripción completa

Detalles Bibliográficos
Autores principales: Schreiber, Julian Alexander, Derksen, Anastasia, Goerges, Gunnar, Schütte, Sven, Sörgel, Jasmin, Kiper, Aytug K., Strutz-Seebohm, Nathalie, Ruck, Tobias, Meuth, Sven G., Decher, Niels, Seebohm, Guiscard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354012/
https://www.ncbi.nlm.nih.gov/pubmed/37464013
http://dx.doi.org/10.1038/s42003-023-05114-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354012/
https://www.ncbi.nlm.nih.gov/pubmed/37464013
http://dx.doi.org/10.1038/s42003-023-05114-4

Ejemplares similares