Cargando…

Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter

The TWIK-related spinal cord K(+) channel (TRESK, K(2P)18.1) is a K(2P) channel contributing to the maintenance of membrane potentials in various cells. Recently, physiological TRESK function was identified as a key player in T-cell differentiation rendering the channel a new pharmacological target...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schreiber, Julian Alexander, Derksen, Anastasia, Goerges, Gunnar, Schütte, Sven, Sörgel, Jasmin, Kiper, Aytug K., Strutz-Seebohm, Nathalie, Ruck, Tobias, Meuth, Sven G., Decher, Niels, Seebohm, Guiscard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354012/ https://www.ncbi.nlm.nih.gov/pubmed/37464013 http://dx.doi.org/10.1038/s42003-023-05114-4

Ejemplares similares

Paving the Way to Understand Autoantibody-Mediated Epilepsy on the Molecular Level
por: Seebohm, Guiscard, et al.
Publicado: (2015)

Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives
por: Ritter, Nadine, et al.
Publicado: (2023)

Klotho: A new trafficking modifier of Kv7.1/KCNE1 channels
por: Strutz-Seebohm, Nathalie, et al.
Publicado: (2014)

From iPSC towards cardiac tissue—a road under construction
por: Peischard, Stefan, et al.
Publicado: (2017)

Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes
por: Ritter, Nadine, et al.
Publicado: (2023)

Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and Therapies
por: Ho, Huyen Tran, et al.
Publicado: (2021)

A benzodiazepine activator locks K(v)7.1 channels open by electro-mechanical uncoupling
por: Schreiber, Julian A., et al.
Publicado: (2022)

Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity
por: Lübke, Marco, et al.
Publicado: (2020)

NDRG2 phosphorylation provides negative feedback for SGK1-dependent regulation of a kainate receptor in astrocytes
por: Matschke, Veronika, et al.
Publicado: (2015)

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors
por: Schreiber, Julian A., et al.
Publicado: (2019)

Knockout of the Cardiac Transcription Factor NKX2-5 Results in Stem Cell-Derived Cardiac Cells with Typical Purkinje Cell-like Signal Transduction and Extracellular Matrix Formation
por: Disse, Paul, et al.
Publicado: (2023)

An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis
por: Amedonu, Elsie, et al.
Publicado: (2019)

Structural interplay of K(V)7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (K(V)7.1-A287T)
por: Rothenberg, Ina, et al.
Publicado: (2016)

Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system
por: Peischard, Stefan, et al.
Publicado: (2022)

Identification of a Novel Signaling Pathway and Its Relevance for GluA1 Recycling
por: Seebohm, Guiscard, et al.
Publicado: (2012)

The KCNE Tango – How KCNE1 Interacts with Kv7.1
por: Wrobel, Eva, et al.
Publicado: (2012)

Human pluripotent stem cell-derived cardiomyocytes: Genome-wide expression profiling of long-term in vitro maturation in comparison to human heart tissue
por: Piccini, Ilaria, et al.
Publicado: (2015)

In Vitro Model Systems of Coxsackievirus B3-Induced Myocarditis: Comparison of Commonly Used Cell Lines and Characterization of CVB3-Infected iCell(®) Cardiomyocytes
por: Kraft, Lisa, et al.
Publicado: (2021)

Functional high-resolution time-course expression analysis of human embryonic stem cells undergoing cardiac induction
por: Piccini, Ilaria, et al.
Publicado: (2016)

Structural basis of PI(4,5)P(2)-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A)
por: Seebohm, Guiscard, et al.
Publicado: (2014)

Effects of Axonal Demyelination, Inflammatory Cytokines and Divalent Cation Chelators on Thalamic HCN Channels and Oscillatory Bursting
por: Oniani, Tengiz, et al.
Publicado: (2022)

Residues at the tip of the pore loop of NR3B-containing NMDA receptors determine Ca(2+ )permeability and Mg(2+ )block
por: Cavara, Nora A, et al.
Publicado: (2010)

The Linker Pivot in Ci-VSP: The Key to Unlock Catalysis
por: Hobiger, Kirstin, et al.
Publicado: (2013)

An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities
por: Wemhöner, Konstantin, et al.
Publicado: (2015)

The molecular basis for an allosteric inhibition of K(+)-flux gating in K(2P) channels
por: Rinné, Susanne, et al.
Publicado: (2019)

[2.2]Paracyclophane‐Based TCN‐201 Analogs as GluN2A‐Selective NMDA Receptor Antagonists
por: Rajan, Remya, et al.
Publicado: (2021)

The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease
por: Peischard, Stefan, et al.
Publicado: (2020)

Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast K(v)7.1 Recycling
por: Piccini, Ilaria, et al.
Publicado: (2017)

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting
por: Wrobel, Eva, et al.
Publicado: (2016)

Veľký tresk odložili na jar
Publicado: (2008)

Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder
por: Friedrich, Corinna, et al.
Publicado: (2014)

Electrophysiological alterations in a murine model of chronic coxsackievirus B3 myocarditis
por: Kaese, Sven, et al.
Publicado: (2017)

Experiment napodobující Velký třesk právě startuje
Publicado: (2008)

Stimulation of HERG Channel Activity by β-catenin
por: Munoz, Carlos, et al.
Publicado: (2012)

Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells
por: Epping, Lisa, et al.
Publicado: (2022)

Insight into the Molecular Interaction of Cloxyquin (5-chloro-8-hydroxyquinoline) with Bovine Serum Albumin: Biophysical Analysis and Computational Simulation
por: Phopin, Kamonrat, et al.
Publicado: (2019)

Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES
por: Pfeiffer, Martin J., et al.
Publicado: (2018)

Cardiac Subtype-Specific Modeling of K(v)1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells
por: Marczenke, Maike, et al.
Publicado: (2017)

Ptejte se, jak se napodobuje velký třesk
Publicado: (2009)

Modulation of TRESK Background K(+) Channel by Membrane Stretch
por: Callejo, Gerard, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ljb2acenqtq6rsfm3jfvq8u5so