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Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel
Cyclic nucleotide-gated (CNG) channels transduce chemical signals into electrical signals in sensory receptors and neurons. They are activated by cGMP or cAMP, which bind to the cyclic nucleotide-binding domain (CNBD) to open a gate located 50-60 Å away in the central cavity. Structures of closed an...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354024/ https://www.ncbi.nlm.nih.gov/pubmed/37463923 http://dx.doi.org/10.1038/s41467-023-39971-8 |