CTLA4-Ig Effectively Controls Clinical Deterioration and Immune Condition in a Murine Model of Foxp3 Deficiency

PURPOSE: FOXP3 deficiency results in severe multisystem autoimmunity in both mice and humans, driven by the absence of functional regulatory T cells. Patients typically present with early and severe autoimmune polyendocrinopathy, dermatitis, and severe inflammation of the gut, leading to villous atr...

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Detalles Bibliográficos
Autores principales: Gerbaux, Margaux, Roos, Evelyne, Willemsen, Mathijs, Staels, Frederik, Neumann, Julika, Bücken, Leoni, Haughton, Jeason, Yshii, Lidia, Dooley, James, Schlenner, Susan, Humblet-Baron, Stephanie, Liston, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354160/
https://www.ncbi.nlm.nih.gov/pubmed/37156988
http://dx.doi.org/10.1007/s10875-023-01462-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354160/
https://www.ncbi.nlm.nih.gov/pubmed/37156988
http://dx.doi.org/10.1007/s10875-023-01462-2

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