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Allosteric activation of vinculin by talin

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single-molecule magnetic tweezers experiments, Molecular Dynamics simulations, actin-bundling assays, and adhesion as...

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Detalles Bibliográficos
Autores principales:	Franz, Florian, Tapia-Rojo, Rafael, Winograd-Katz, Sabina, Boujemaa-Paterski, Rajaa, Li, Wenhong, Unger, Tamar, Albeck, Shira, Aponte-Santamaria, Camilo, Garcia-Manyes, Sergi, Medalia, Ohad, Geiger, Benjamin, Gräter, Frauke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354202/ https://www.ncbi.nlm.nih.gov/pubmed/37463895 http://dx.doi.org/10.1038/s41467-023-39646-4

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