Cargando…

Allosteric activation of vinculin by talin

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single-molecule magnetic tweezers experiments, Molecular Dynamics simulations, actin-bundling assays, and adhesion as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Franz, Florian, Tapia-Rojo, Rafael, Winograd-Katz, Sabina, Boujemaa-Paterski, Rajaa, Li, Wenhong, Unger, Tamar, Albeck, Shira, Aponte-Santamaria, Camilo, Garcia-Manyes, Sergi, Medalia, Ohad, Geiger, Benjamin, Gräter, Frauke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354202/ https://www.ncbi.nlm.nih.gov/pubmed/37463895 http://dx.doi.org/10.1038/s41467-023-39646-4

Ejemplares similares

Talin-activated vinculin interacts with branched actin networks to initiate bundles
por: Boujemaa-Paterski, Rajaa, et al.
Publicado: (2020)

Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape
por: Tapia-Rojo, Rafael, et al.
Publicado: (2023)

A network of mixed actin polarity in the leading edge of spreading cells
por: Chung, Wen-Lu, et al.
Publicado: (2022)

The Actin Network Interfacing Diverse Integrin-Mediated Adhesions
por: Geiger, Benjamin, et al.
Publicado: (2023)

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation
por: Yao, Mingxi, et al.
Publicado: (2014)

Vinculin controls focal adhesion formation by direct interactions with talin and actin
por: Humphries, Jonathan D., et al.
Publicado: (2007)

Vinculin controls talin engagement with the actomyosin machinery
por: Atherton, Paul, et al.
Publicado: (2015)

Direct observation of a coil-to-helix contraction triggered by vinculin binding to talin
por: Tapia-Rojo, Rafael, et al.
Publicado: (2020)

Chlamydial virulence factor TarP mimics talin to disrupt the talin‐vinculin complex
por: Whitewood, Austin J., et al.
Publicado: (2018)

Vinculins interaction with talin is essential for mammary epithelial differentiation
por: Wang, Pengbo, et al.
Publicado: (2019)

Identification of a talin binding site in the cytoskeletal protein vinculin
Publicado: (1989)

Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin
por: Kelley, Charlotte F, et al.
Publicado: (2020)

Relief of talin autoinhibition triggers a force-independent association with vinculin
por: Atherton, Paul, et al.
Publicado: (2019)

Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease
por: Aoyama, Masayuki, et al.
Publicado: (2022)

The Multicellular Effects of VDAC1 N-Terminal-Derived Peptide
por: Anand, Uttpal, et al.
Publicado: (2022)

Conformational states during vinculin unlocking differentially regulate focal adhesion properties
por: Chorev, Dror S., et al.
Publicado: (2018)

The cytoskeletal protein talin contains at least two distinct vinculin binding domains
Publicado: (1993)

Talin and vinculin play distinct roles in filopodial motility in the neuronal growth cone
Publicado: (1996)

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin
por: Margadant, Felix, et al.
Publicado: (2011)

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin
por: Gingras, Alexandre R., et al.
Publicado: (2010)

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover
por: Goult, Benjamin T., et al.
Publicado: (2013)

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring
por: Ciobanasu, Corina, et al.
Publicado: (2014)

Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force
por: Vigouroux, Clémence, et al.
Publicado: (2020)

Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation
por: Han, Sangyoon J, et al.
Publicado: (2021)

How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism
por: Hytönen, Vesa P, et al.
Publicado: (2008)

Accessibility explains preferred thiol-disulfide isomerization in a protein domain
por: Kolšek, Katra, et al.
Publicado: (2017)

Myristoyl’s dual role in allosterically regulating and localizing Abl kinase
por: de Buhr, Svenja, et al.
Publicado: (2023)

Increased talin–vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections
por: Liu, Yakun, et al.
Publicado: (2020)

Direct single-molecule quantification reveals unexpectedly high mechanical stability of vinculin—talin/α-catenin linkages
por: Le, Shimin, et al.
Publicado: (2019)

One-Way Allosteric Communication between the Two Disulfide Bonds in Tissue Factor
por: Zhou, Beifei, et al.
Publicado: (2017)

The domain structure of talin: Residues 1815–1973 form a five-helix bundle containing a cryptic vinculin-binding site
por: Goult, Benjamin T., et al.
Publicado: (2010)

An Allosteric Signaling Pathway of Human 3-Phosphoglycerate Kinase from Force Distribution Analysis
por: Palmai, Zoltan, et al.
Publicado: (2014)

ATP allosterically stabilizes integrin-linked kinase for efficient force generation
por: Martin, Isabel M., et al.
Publicado: (2022)

Mechanism of Focal Adhesion Kinase Mechanosensing
por: Zhou, Jing, et al.
Publicado: (2015)

Network heterogeneity regulates steering in actin-based motility
por: Boujemaa-Paterski, Rajaa, et al.
Publicado: (2017)

Turnover of branched actin filament networks by stochastic fragmentation with ADF/cofilin
por: Reymann, Anne-Cécile, et al.
Publicado: (2011)

Quantitative regulation of the dynamic steady state of actin networks
por: Manhart, Angelika, et al.
Publicado: (2019)

LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex
por: Zacharchenko, Thomas, et al.
Publicado: (2016)

Vinculin minds the gap
por: Leslie, Mitch
Publicado: (2012)

The Interaction of Vinculin with Actin
por: Golji, Javad, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_mb2nsm9t935as7mr4j8u3gqofi