Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Muscle-specific tyrosine kinase myasthenia gravis (MuSK MG) is an autoimmune disease that causes life-threatening muscle weakness due to anti-MuSK autoantibodies that disrupt neuromuscular junction signaling. To avoid chronic immunosuppression from current therapies, we engineered T cells to express...

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Detalles Bibliográficos
Autores principales: Oh, Sangwook, Mao, Xuming, Manfredo-Vieira, Silvio, Lee, Jinmin, Patel, Darshil, Choi, Eun Jung, Alvarado, Andrea, Cottman-Thomas, Ebony, Maseda, Damian, Tsao, Patricia Y., Ellebrecht, Christoph T., Khella, Sami L., Richman, David P., O’Connor, Kevin C., Herzberg, Uri, Binder, Gwendolyn K., Milone, Michael C., Basu, Samik, Payne, Aimee S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354218/
https://www.ncbi.nlm.nih.gov/pubmed/36658341
http://dx.doi.org/10.1038/s41587-022-01637-z

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