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A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility
PURPOSE: Ischemic stroke (IS), a serious cerebrovascular disease, greatly affects people's health and life. Genetic factors are indispensable for the occurrence of IS. As a biomarker for IS, the MMP-9 gene is widely involved in the pathophysiological process of IS. This study attempts to find o...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354235/ https://www.ncbi.nlm.nih.gov/pubmed/37475739 http://dx.doi.org/10.3389/fneur.2023.1178642 |
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author | Ge, Hanming Ma, Xiaojuan Wang, Jiachen Zhang, Xiaobo Zhang, Yu Zhang, Qi Li, Wu Liu, Jie Duan, Jinwei Shi, Wenzhen Tian, Ye |
author_facet | Ge, Hanming Ma, Xiaojuan Wang, Jiachen Zhang, Xiaobo Zhang, Yu Zhang, Qi Li, Wu Liu, Jie Duan, Jinwei Shi, Wenzhen Tian, Ye |
author_sort | Ge, Hanming |
collection | PubMed |
description | PURPOSE: Ischemic stroke (IS), a serious cerebrovascular disease, greatly affects people's health and life. Genetic factors are indispensable for the occurrence of IS. As a biomarker for IS, the MMP-9 gene is widely involved in the pathophysiological process of IS. This study attempts to find out the relationship between MMP-9 polymorphisms and IS susceptibility. METHODS: A total of 700 IS patients and 700 healthy controls were recruited. The single nucleotide polymorphism (SNP) markers of the MMP-9 gene were genotyped by the MassARRAY analyzer. Multifactor dimensionality reduction (MDR) was applied to generate SNP–SNP interaction. Furthermore, the relationship between genetic variations (allele and genotype) of the MMP-9 gene and IS susceptibility was analyzed by calculating odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Our results demonstrated that rs2250889 could significantly increase the susceptibility to IS in the codominant, dominant, overdominant, and log-additive models (p < 0.05). Further stratification analysis showed that compared with the control group, rs2250889 was associated with IS risk in different case groups (age, female, smoking, and non-drinking) (p < 0.05). Based on MDR analysis, rs2250889 was the best model for predicting IS risk (cross-validation consistency: 10/10, OR = 1.56 (1.26–1.94), p < 0.001). CONCLUSION: Our study preliminarily confirmed that SNP rs2250889 was significantly associated with susceptibility to IS. |
format | Online Article Text |
id | pubmed-10354235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103542352023-07-20 A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility Ge, Hanming Ma, Xiaojuan Wang, Jiachen Zhang, Xiaobo Zhang, Yu Zhang, Qi Li, Wu Liu, Jie Duan, Jinwei Shi, Wenzhen Tian, Ye Front Neurol Neurology PURPOSE: Ischemic stroke (IS), a serious cerebrovascular disease, greatly affects people's health and life. Genetic factors are indispensable for the occurrence of IS. As a biomarker for IS, the MMP-9 gene is widely involved in the pathophysiological process of IS. This study attempts to find out the relationship between MMP-9 polymorphisms and IS susceptibility. METHODS: A total of 700 IS patients and 700 healthy controls were recruited. The single nucleotide polymorphism (SNP) markers of the MMP-9 gene were genotyped by the MassARRAY analyzer. Multifactor dimensionality reduction (MDR) was applied to generate SNP–SNP interaction. Furthermore, the relationship between genetic variations (allele and genotype) of the MMP-9 gene and IS susceptibility was analyzed by calculating odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Our results demonstrated that rs2250889 could significantly increase the susceptibility to IS in the codominant, dominant, overdominant, and log-additive models (p < 0.05). Further stratification analysis showed that compared with the control group, rs2250889 was associated with IS risk in different case groups (age, female, smoking, and non-drinking) (p < 0.05). Based on MDR analysis, rs2250889 was the best model for predicting IS risk (cross-validation consistency: 10/10, OR = 1.56 (1.26–1.94), p < 0.001). CONCLUSION: Our study preliminarily confirmed that SNP rs2250889 was significantly associated with susceptibility to IS. Frontiers Media S.A. 2023-07-05 /pmc/articles/PMC10354235/ /pubmed/37475739 http://dx.doi.org/10.3389/fneur.2023.1178642 Text en Copyright © 2023 Ge, Ma, Wang, Zhang, Zhang, Zhang, Li, Liu, Duan, Shi and Tian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Ge, Hanming Ma, Xiaojuan Wang, Jiachen Zhang, Xiaobo Zhang, Yu Zhang, Qi Li, Wu Liu, Jie Duan, Jinwei Shi, Wenzhen Tian, Ye A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility |
title | A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility |
title_full | A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility |
title_fullStr | A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility |
title_full_unstemmed | A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility |
title_short | A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility |
title_sort | potential relationship between mmp-9 rs2250889 and ischemic stroke susceptibility |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354235/ https://www.ncbi.nlm.nih.gov/pubmed/37475739 http://dx.doi.org/10.3389/fneur.2023.1178642 |
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