Research progress on Cornus officinalis and its active compounds in the treatment of diabetic nephropathy

Diabetic nephropathy (DN) is a kidney disorder secondary to diabetes and is one of the main diabetic microvascular complications. As the number of diabetic patients grows, DN has become the leading cause of chronic kidney disease in China. Unfortunately, no definitive cure currently exists for DN. C...

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Autores principales: Wu, Chenguang, Wang, Jingjing, Zhang, Rui, Zhao, Hailing, Li, Xin, Wang, Lifan, Liu, Peng, Li, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354237/
https://www.ncbi.nlm.nih.gov/pubmed/37475719
http://dx.doi.org/10.3389/fphar.2023.1207777
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author Wu, Chenguang
Wang, Jingjing
Zhang, Rui
Zhao, Hailing
Li, Xin
Wang, Lifan
Liu, Peng
Li, Ping
author_facet Wu, Chenguang
Wang, Jingjing
Zhang, Rui
Zhao, Hailing
Li, Xin
Wang, Lifan
Liu, Peng
Li, Ping
author_sort Wu, Chenguang
collection PubMed
description Diabetic nephropathy (DN) is a kidney disorder secondary to diabetes and is one of the main diabetic microvascular complications. As the number of diabetic patients grows, DN has become the leading cause of chronic kidney disease in China. Unfortunately, no definitive cure currently exists for DN. Cornus officinalis (CO), frequently utilized in clinical settings for diabetes mellitus treatment, has proven vital in both preventing and treating DN. This article explores the pathogenesis of DN and how CO and its active compounds regulate glucose and lipid metabolism, exhibit anti-inflammatory properties, inhibit oxidative stress, regulate podocytes, and manage autophagy. The mechanism and role of and its active compounds in the treatment of DN are discussed.
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spelling pubmed-103542372023-07-20 Research progress on Cornus officinalis and its active compounds in the treatment of diabetic nephropathy Wu, Chenguang Wang, Jingjing Zhang, Rui Zhao, Hailing Li, Xin Wang, Lifan Liu, Peng Li, Ping Front Pharmacol Pharmacology Diabetic nephropathy (DN) is a kidney disorder secondary to diabetes and is one of the main diabetic microvascular complications. As the number of diabetic patients grows, DN has become the leading cause of chronic kidney disease in China. Unfortunately, no definitive cure currently exists for DN. Cornus officinalis (CO), frequently utilized in clinical settings for diabetes mellitus treatment, has proven vital in both preventing and treating DN. This article explores the pathogenesis of DN and how CO and its active compounds regulate glucose and lipid metabolism, exhibit anti-inflammatory properties, inhibit oxidative stress, regulate podocytes, and manage autophagy. The mechanism and role of and its active compounds in the treatment of DN are discussed. Frontiers Media S.A. 2023-07-05 /pmc/articles/PMC10354237/ /pubmed/37475719 http://dx.doi.org/10.3389/fphar.2023.1207777 Text en Copyright © 2023 Wu, Wang, Zhang, Zhao, Li, Wang, Liu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Wu, Chenguang
Wang, Jingjing
Zhang, Rui
Zhao, Hailing
Li, Xin
Wang, Lifan
Liu, Peng
Li, Ping
Research progress on Cornus officinalis and its active compounds in the treatment of diabetic nephropathy
title Research progress on Cornus officinalis and its active compounds in the treatment of diabetic nephropathy
title_full Research progress on Cornus officinalis and its active compounds in the treatment of diabetic nephropathy
title_fullStr Research progress on Cornus officinalis and its active compounds in the treatment of diabetic nephropathy
title_full_unstemmed Research progress on Cornus officinalis and its active compounds in the treatment of diabetic nephropathy
title_short Research progress on Cornus officinalis and its active compounds in the treatment of diabetic nephropathy
title_sort research progress on cornus officinalis and its active compounds in the treatment of diabetic nephropathy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354237/
https://www.ncbi.nlm.nih.gov/pubmed/37475719
http://dx.doi.org/10.3389/fphar.2023.1207777
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