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Pregnancy related hormones increase CYP3A mediated buprenorphine metabolism in human hepatocytes: a comparison to CYP3A substrates nifedipine and midazolam

Introduction: Pregnancy increases the clearance of CYP3A4 substrate drugs and pregnancy-related hormones (PRHs) induce hepatic CYP3A4 expression and metabolism. However, it remains unclear to what extent the magnitude of PRH-evoked changes in hepatic CYP3A metabolism varies across multiple substrate...

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Detalles Bibliográficos
Autores principales:	Fashe, Muluneh M., Miner, Taryn A., Fallon, John K., Schauer, Amanda P., Sykes, Craig, Smith, Philip C., Lee, Craig R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354249/ https://www.ncbi.nlm.nih.gov/pubmed/37475714 http://dx.doi.org/10.3389/fphar.2023.1218703

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