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Interplay between RNA interference and transposable elements in mammals

RNA interference (RNAi) plays pleiotropic roles in animal cells, from the post-transcriptional control of gene expression via the production of micro-RNAs, to the inhibition of RNA virus infection. We discuss here the role of RNAi in regulating the expression of self RNAs, and particularly transposa...

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Detalles Bibliográficos
Autores principales: Cornec, Alexis, Poirier, Enzo Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354258/
https://www.ncbi.nlm.nih.gov/pubmed/37475864
http://dx.doi.org/10.3389/fimmu.2023.1212086
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author Cornec, Alexis
Poirier, Enzo Z.
author_facet Cornec, Alexis
Poirier, Enzo Z.
author_sort Cornec, Alexis
collection PubMed
description RNA interference (RNAi) plays pleiotropic roles in animal cells, from the post-transcriptional control of gene expression via the production of micro-RNAs, to the inhibition of RNA virus infection. We discuss here the role of RNAi in regulating the expression of self RNAs, and particularly transposable elements (TEs), which are genomic sequences capable of influencing gene expression and disrupting genome architecture. Dicer proteins act as the entry point of the RNAi pathway by detecting and degrading RNA of TE origin, ultimately leading to TE silencing. RNAi similarly targets cellular RNAs such as repeats transcribed from centrosomes. Dicer proteins are thus nucleic acid sensors that recognize self RNA in the form of double-stranded RNA, and trigger a silencing RNA interference response.
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spelling pubmed-103542582023-07-20 Interplay between RNA interference and transposable elements in mammals Cornec, Alexis Poirier, Enzo Z. Front Immunol Immunology RNA interference (RNAi) plays pleiotropic roles in animal cells, from the post-transcriptional control of gene expression via the production of micro-RNAs, to the inhibition of RNA virus infection. We discuss here the role of RNAi in regulating the expression of self RNAs, and particularly transposable elements (TEs), which are genomic sequences capable of influencing gene expression and disrupting genome architecture. Dicer proteins act as the entry point of the RNAi pathway by detecting and degrading RNA of TE origin, ultimately leading to TE silencing. RNAi similarly targets cellular RNAs such as repeats transcribed from centrosomes. Dicer proteins are thus nucleic acid sensors that recognize self RNA in the form of double-stranded RNA, and trigger a silencing RNA interference response. Frontiers Media S.A. 2023-07-05 /pmc/articles/PMC10354258/ /pubmed/37475864 http://dx.doi.org/10.3389/fimmu.2023.1212086 Text en Copyright © 2023 Cornec and Poirier https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cornec, Alexis
Poirier, Enzo Z.
Interplay between RNA interference and transposable elements in mammals
title Interplay between RNA interference and transposable elements in mammals
title_full Interplay between RNA interference and transposable elements in mammals
title_fullStr Interplay between RNA interference and transposable elements in mammals
title_full_unstemmed Interplay between RNA interference and transposable elements in mammals
title_short Interplay between RNA interference and transposable elements in mammals
title_sort interplay between rna interference and transposable elements in mammals
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354258/
https://www.ncbi.nlm.nih.gov/pubmed/37475864
http://dx.doi.org/10.3389/fimmu.2023.1212086
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