Efficacious switching from subcutaneous to intravenous tocilizumab in patients with non-infectious non-anterior uveitis

PURPOSE: The efficacy of tocilizumab in refractory chronic noninfectious uveitis has been previously reported, but no data comparing intravenous and subcutaneous tocilizumab in uveitis are available. RESULTS: We report a case series of patients with chronic noninfectious uveitis with incomplete effi...

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Detalles Bibliográficos
Autores principales: Leclercq, Mathilde, Goupillou, Paul, Gomez, Hélène, Muraine, Marc, Benhamou, Ygal, Girszyn, Nicolas, Gueudry, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354347/
https://www.ncbi.nlm.nih.gov/pubmed/37462850
http://dx.doi.org/10.1186/s12348-023-00336-3
Descripción
Sumario:PURPOSE: The efficacy of tocilizumab in refractory chronic noninfectious uveitis has been previously reported, but no data comparing intravenous and subcutaneous tocilizumab in uveitis are available. RESULTS: We report a case series of patients with chronic noninfectious uveitis with incomplete efficacy of subcutaneous tocilizumab, improved after switching to intravenous routes. Improvement of visual acuity was observed with intravenous tocilizumab for all patients. Half of the patients could stop corticosteroids. Rapid efficacy of intravenous tocilizumab was observed, between 2 and 3 months. CONCLUSION: In uveitis, tocilizumab administration could be optimized by a switching from a subcutaneous to an intravenous administration route.

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