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Roles and implications of mRNA N(6) ‐methyladenosine in cancer

RNA N (6)‐methyladenosine modification is the most prevalent internal modification of eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased attention. To date, m(6)A modification has been shown to impact multiple RNA metabolic processes and play a vital role in num...

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Autores principales: Zeng, Lingxing, Huang, Xudong, Zhang, Jialiang, Lin, Dongxin, Zheng, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354418/
https://www.ncbi.nlm.nih.gov/pubmed/37350762
http://dx.doi.org/10.1002/cac2.12458
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author Zeng, Lingxing
Huang, Xudong
Zhang, Jialiang
Lin, Dongxin
Zheng, Jian
author_facet Zeng, Lingxing
Huang, Xudong
Zhang, Jialiang
Lin, Dongxin
Zheng, Jian
author_sort Zeng, Lingxing
collection PubMed
description RNA N (6)‐methyladenosine modification is the most prevalent internal modification of eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased attention. To date, m(6)A modification has been shown to impact multiple RNA metabolic processes and play a vital role in numerous biological processes. Recent evidence suggests that aberrant m(6)A modification is a hallmark of cancer, and it plays a critical role in cancer development and progression through multiple mechanisms. Here, we review the biological functions of mRNA m(6)A modification in various types of cancers, with a particular focus on metabolic reprogramming, programmed cell death and tumor metastasis. Furthermore, we discuss the potential of targeting m(6)A modification or its regulatory proteins as a novel approach of cancer therapy and the progress of research on m(6)A modification in tumor immunity and immunotherapy. Finally, we summarize the development of different m(6)A detection methods and their advantages and disadvantages.
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spelling pubmed-103544182023-07-20 Roles and implications of mRNA N(6) ‐methyladenosine in cancer Zeng, Lingxing Huang, Xudong Zhang, Jialiang Lin, Dongxin Zheng, Jian Cancer Commun (Lond) Review RNA N (6)‐methyladenosine modification is the most prevalent internal modification of eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased attention. To date, m(6)A modification has been shown to impact multiple RNA metabolic processes and play a vital role in numerous biological processes. Recent evidence suggests that aberrant m(6)A modification is a hallmark of cancer, and it plays a critical role in cancer development and progression through multiple mechanisms. Here, we review the biological functions of mRNA m(6)A modification in various types of cancers, with a particular focus on metabolic reprogramming, programmed cell death and tumor metastasis. Furthermore, we discuss the potential of targeting m(6)A modification or its regulatory proteins as a novel approach of cancer therapy and the progress of research on m(6)A modification in tumor immunity and immunotherapy. Finally, we summarize the development of different m(6)A detection methods and their advantages and disadvantages. John Wiley and Sons Inc. 2023-06-23 /pmc/articles/PMC10354418/ /pubmed/37350762 http://dx.doi.org/10.1002/cac2.12458 Text en © 2023 The Authors. Cancer Communications published by John Wiley & Sons Australia, Ltd. on behalf of Sun Yat‐sen University Cancer Center. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review
Zeng, Lingxing
Huang, Xudong
Zhang, Jialiang
Lin, Dongxin
Zheng, Jian
Roles and implications of mRNA N(6) ‐methyladenosine in cancer
title Roles and implications of mRNA N(6) ‐methyladenosine in cancer
title_full Roles and implications of mRNA N(6) ‐methyladenosine in cancer
title_fullStr Roles and implications of mRNA N(6) ‐methyladenosine in cancer
title_full_unstemmed Roles and implications of mRNA N(6) ‐methyladenosine in cancer
title_short Roles and implications of mRNA N(6) ‐methyladenosine in cancer
title_sort roles and implications of mrna n(6) ‐methyladenosine in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354418/
https://www.ncbi.nlm.nih.gov/pubmed/37350762
http://dx.doi.org/10.1002/cac2.12458
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