TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

Loss-of-function mutations in the lysosomal nucleoside transporter SLC29A3 cause lysosomal nucleoside storage and histiocytosis: phagocyte accumulation in multiple organs. However, little is known about the mechanism by which lysosomal nucleoside storage drives histiocytosis. Herein, histiocytosis i...

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Detalles Bibliográficos
Autores principales: Shibata, Takuma, Sato, Ryota, Taoka, Masato, Saitoh, Shin-Ichiroh, Komine, Mayumi, Yamaguchi, Kiyoshi, Goyama, Susumu, Motoi, Yuji, Kitaura, Jiro, Izawa, Kumi, Yamauchi, Yoshio, Tsukamoto, Yumiko, Ichinohe, Takeshi, Fujita, Etsuko, Hiranuma, Ryosuke, Fukui, Ryutaro, Furukawa, Yoichi, Kitamura, Toshio, Takai, Toshiyuki, Tojo, Arinobu, Ohtsuki, Mamitaro, Ohto, Umeharu, Shimizu, Toshiyuki, Ozawa, Manabu, Yoshida, Nobuaki, Isobe, Toshiaki, Latz, Eicke, Mukai, Kojiro, Taguchi, Tomohiko, Hemmi, Hiroaki, Akira, Shizuo, Miyake, Kensuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354536/
https://www.ncbi.nlm.nih.gov/pubmed/37462944
http://dx.doi.org/10.1084/jem.20230054

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