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A dual-core NMR system for field-cycling singlet assisted diffusion NMR
Long-lived singlet spin order offers the possibility to extend the spin memory by more than an order of magnitude. This enhancement can be used, among other applications, to assist NMR diffusion experiments in porous media where the extended lifetime of singlet spin order can be used to gain informa...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354561/ https://www.ncbi.nlm.nih.gov/pubmed/37476652 http://dx.doi.org/10.3389/fchem.2023.1229586 |
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author | Robertson, Thomas B. R. Bannister, Rose C. Cartlidge, Topaz A. A. Hugger, Thimo Breham, Sebastien Zick, Klaus Engelke, Frank Thompson, Sam Pileio, Giuseppe |
author_facet | Robertson, Thomas B. R. Bannister, Rose C. Cartlidge, Topaz A. A. Hugger, Thimo Breham, Sebastien Zick, Klaus Engelke, Frank Thompson, Sam Pileio, Giuseppe |
author_sort | Robertson, Thomas B. R. |
collection | PubMed |
description | Long-lived singlet spin order offers the possibility to extend the spin memory by more than an order of magnitude. This enhancement can be used, among other applications, to assist NMR diffusion experiments in porous media where the extended lifetime of singlet spin order can be used to gain information about structural features of the medium as well as the dynamics of the imbibed phase. Other than offering the possibility to explore longer diffusion times of the order of many minutes that, for example, gives unprecedented access to tortuosity in structures with interconnected pores, singlet order has the important advantage to be immune to the internal field gradients generated by magnetic susceptibility inhomogeneities. These inhomogeneities, however, are responsible for very short T(2) decay constants in high magnetic field and this precludes access to the singlet order in the first instance. To overcome this difficulty and take advantage of singlet order in diffusion experiments in porous media, we have here developed a dual-core system with radiofrequency and 3-axis pulsed field gradients facilities in low magnetic field, for preparation and manipulation of singlet order and a probe, in high magnetic field, for polarisation and detection. The system operates in field-cycling and can be used for a variety of NMR experiments including diffusion tensor imaging (both singlet assisted and not). In this paper we present and discuss the new hardware and its calibration, and demonstrate its capabilities through a variety of examples. |
format | Online Article Text |
id | pubmed-10354561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103545612023-07-20 A dual-core NMR system for field-cycling singlet assisted diffusion NMR Robertson, Thomas B. R. Bannister, Rose C. Cartlidge, Topaz A. A. Hugger, Thimo Breham, Sebastien Zick, Klaus Engelke, Frank Thompson, Sam Pileio, Giuseppe Front Chem Chemistry Long-lived singlet spin order offers the possibility to extend the spin memory by more than an order of magnitude. This enhancement can be used, among other applications, to assist NMR diffusion experiments in porous media where the extended lifetime of singlet spin order can be used to gain information about structural features of the medium as well as the dynamics of the imbibed phase. Other than offering the possibility to explore longer diffusion times of the order of many minutes that, for example, gives unprecedented access to tortuosity in structures with interconnected pores, singlet order has the important advantage to be immune to the internal field gradients generated by magnetic susceptibility inhomogeneities. These inhomogeneities, however, are responsible for very short T(2) decay constants in high magnetic field and this precludes access to the singlet order in the first instance. To overcome this difficulty and take advantage of singlet order in diffusion experiments in porous media, we have here developed a dual-core system with radiofrequency and 3-axis pulsed field gradients facilities in low magnetic field, for preparation and manipulation of singlet order and a probe, in high magnetic field, for polarisation and detection. The system operates in field-cycling and can be used for a variety of NMR experiments including diffusion tensor imaging (both singlet assisted and not). In this paper we present and discuss the new hardware and its calibration, and demonstrate its capabilities through a variety of examples. Frontiers Media S.A. 2023-07-05 /pmc/articles/PMC10354561/ /pubmed/37476652 http://dx.doi.org/10.3389/fchem.2023.1229586 Text en Copyright © 2023 Robertson, Bannister, Cartlidge, Hugger, Breham, Zick, Engelke, Thompson and Pileio. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Robertson, Thomas B. R. Bannister, Rose C. Cartlidge, Topaz A. A. Hugger, Thimo Breham, Sebastien Zick, Klaus Engelke, Frank Thompson, Sam Pileio, Giuseppe A dual-core NMR system for field-cycling singlet assisted diffusion NMR |
title | A dual-core NMR system for field-cycling singlet assisted diffusion NMR |
title_full | A dual-core NMR system for field-cycling singlet assisted diffusion NMR |
title_fullStr | A dual-core NMR system for field-cycling singlet assisted diffusion NMR |
title_full_unstemmed | A dual-core NMR system for field-cycling singlet assisted diffusion NMR |
title_short | A dual-core NMR system for field-cycling singlet assisted diffusion NMR |
title_sort | dual-core nmr system for field-cycling singlet assisted diffusion nmr |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354561/ https://www.ncbi.nlm.nih.gov/pubmed/37476652 http://dx.doi.org/10.3389/fchem.2023.1229586 |
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