The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis

NMR metabolomics is a powerful tool to characterise the changes in cancer cell metabolism elicited by anticancer drugs. Here, the large metabolic alterations produced by two cytotoxic gold carbene compounds in A2780 ovarian cancer cells are described and discussed in comparison to auranofin, in the...

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Autores principales: Ghini, Veronica, Mannelli, Michele, Massai, Lara, Geri, Andrea, Zineddu, Stefano, Gamberi, Tania, Messori, Luigi, Turano, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354608/
https://www.ncbi.nlm.nih.gov/pubmed/37476042
http://dx.doi.org/10.1039/d3ra04032a
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author Ghini, Veronica
Mannelli, Michele
Massai, Lara
Geri, Andrea
Zineddu, Stefano
Gamberi, Tania
Messori, Luigi
Turano, Paola
author_facet Ghini, Veronica
Mannelli, Michele
Massai, Lara
Geri, Andrea
Zineddu, Stefano
Gamberi, Tania
Messori, Luigi
Turano, Paola
author_sort Ghini, Veronica
collection PubMed
description NMR metabolomics is a powerful tool to characterise the changes in cancer cell metabolism elicited by anticancer drugs. Here, the large metabolic alterations produced by two cytotoxic gold carbene compounds in A2780 ovarian cancer cells are described and discussed in comparison to auranofin, in the frame of the available mechanistic knowledge.
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spelling pubmed-103546082023-07-20 The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis Ghini, Veronica Mannelli, Michele Massai, Lara Geri, Andrea Zineddu, Stefano Gamberi, Tania Messori, Luigi Turano, Paola RSC Adv Chemistry NMR metabolomics is a powerful tool to characterise the changes in cancer cell metabolism elicited by anticancer drugs. Here, the large metabolic alterations produced by two cytotoxic gold carbene compounds in A2780 ovarian cancer cells are described and discussed in comparison to auranofin, in the frame of the available mechanistic knowledge. The Royal Society of Chemistry 2023-07-19 /pmc/articles/PMC10354608/ /pubmed/37476042 http://dx.doi.org/10.1039/d3ra04032a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Ghini, Veronica
Mannelli, Michele
Massai, Lara
Geri, Andrea
Zineddu, Stefano
Gamberi, Tania
Messori, Luigi
Turano, Paola
The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis
title The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis
title_full The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis
title_fullStr The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis
title_full_unstemmed The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis
title_short The effects of two cytotoxic gold(i) carbene compounds on the metabolism of A2780 ovarian cancer cells: mechanistic inferences through NMR analysis
title_sort effects of two cytotoxic gold(i) carbene compounds on the metabolism of a2780 ovarian cancer cells: mechanistic inferences through nmr analysis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354608/
https://www.ncbi.nlm.nih.gov/pubmed/37476042
http://dx.doi.org/10.1039/d3ra04032a
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