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Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report

An 80-year-old male presented with T1N0M0 myxofibrosarcoma in or next to the humeral canal, which is located between the biceps and triceps of the right upper arm. Because the tumor was close to critical anatomical structures such as the brachial artery, median nerve and ulnar nerve, it was deemed i...

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Autores principales: Murakami, Naoya, Nakatani, Fumihiko, Takahashi, Kana, Nakamura, Satoshi, Igaki, Hiroshi, Shikama, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354856/
https://www.ncbi.nlm.nih.gov/pubmed/37301983
http://dx.doi.org/10.1093/jrr/rrad041
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author Murakami, Naoya
Nakatani, Fumihiko
Takahashi, Kana
Nakamura, Satoshi
Igaki, Hiroshi
Shikama, Naoto
author_facet Murakami, Naoya
Nakatani, Fumihiko
Takahashi, Kana
Nakamura, Satoshi
Igaki, Hiroshi
Shikama, Naoto
author_sort Murakami, Naoya
collection PubMed
description An 80-year-old male presented with T1N0M0 myxofibrosarcoma in or next to the humeral canal, which is located between the biceps and triceps of the right upper arm. Because the tumor was close to critical anatomical structures such as the brachial artery, median nerve and ulnar nerve, it was deemed impossible to perform limb-sparing surgery with an adequate resection margin. Therefore, preoperative external beam radiation therapy (EBRT) followed by limb-sparing surgery was offered. Magnetic resonance imaging taken after 40 Gy/20 fractions of EBRT showed an inadequate response, and limb-sparing surgery was not deemed possible at this point. Amputation of the right arm was offered, but the patient refused. Therefore, salvage high-dose-rate interstitial brachytherapy (HDR-ISBT) was offered. Under local anesthesia and sedation, 14 plastic needles were inserted, and 36 Gy in 6 fractions of HDR-ISBT was performed. Although radiation-induced incomplete paralysis of the median nerve was noted, no local progression or distant metastasis was found on the CT that was taken 2 years after the treatment.
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spelling pubmed-103548562023-07-20 Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report Murakami, Naoya Nakatani, Fumihiko Takahashi, Kana Nakamura, Satoshi Igaki, Hiroshi Shikama, Naoto J Radiat Res Technical report An 80-year-old male presented with T1N0M0 myxofibrosarcoma in or next to the humeral canal, which is located between the biceps and triceps of the right upper arm. Because the tumor was close to critical anatomical structures such as the brachial artery, median nerve and ulnar nerve, it was deemed impossible to perform limb-sparing surgery with an adequate resection margin. Therefore, preoperative external beam radiation therapy (EBRT) followed by limb-sparing surgery was offered. Magnetic resonance imaging taken after 40 Gy/20 fractions of EBRT showed an inadequate response, and limb-sparing surgery was not deemed possible at this point. Amputation of the right arm was offered, but the patient refused. Therefore, salvage high-dose-rate interstitial brachytherapy (HDR-ISBT) was offered. Under local anesthesia and sedation, 14 plastic needles were inserted, and 36 Gy in 6 fractions of HDR-ISBT was performed. Although radiation-induced incomplete paralysis of the median nerve was noted, no local progression or distant metastasis was found on the CT that was taken 2 years after the treatment. Oxford University Press 2023-06-10 /pmc/articles/PMC10354856/ /pubmed/37301983 http://dx.doi.org/10.1093/jrr/rrad041 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technical report
Murakami, Naoya
Nakatani, Fumihiko
Takahashi, Kana
Nakamura, Satoshi
Igaki, Hiroshi
Shikama, Naoto
Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report
title Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report
title_full Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report
title_fullStr Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report
title_full_unstemmed Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report
title_short Salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report
title_sort salvage high-dose rate brachytherapy for myxofibrosarcoma of the brachium: a technical report
topic Technical report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10354856/
https://www.ncbi.nlm.nih.gov/pubmed/37301983
http://dx.doi.org/10.1093/jrr/rrad041
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